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Clinical significance of immunoglobulin E responses to staphylococcal superantigens in patients with aspirin-exacerbated respiratory disease.
DC Field | Value | Language |
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dc.contributor.author | Yoo, HS | - |
dc.contributor.author | Shin, YS | - |
dc.contributor.author | Liu, JN | - |
dc.contributor.author | Kim, MA | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2014-05-22T05:40:37Z | - |
dc.date.available | 2014-05-22T05:40:37Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/10074 | - |
dc.description.abstract | BACKGROUND: Previous studies have reported a higher prevalence of immunoglobulin E (IgE) specific for staphylococcal superantigens (SAg) in the nasal mucosa of patients with aspirin-exacerbated respiratory disease (AERD), associated with eosinophilic inflammation and leukotriene production. However, the role of SAg-specific IgE in the pathogenesis of AERD is not well understood. We evaluated the clinical significance of serum IgE specific for three types of SAg, namely staphylococcal enterotoxins A and B (SEA and SEB) and toxic shock syndrome toxin-1 (TSST-1) in AERD.
METHODS: We enrolled 147 patients with AERD confirmed by a lysine-acetyl salicylic acid bronchoprovocative test and compared them with 147 patients with aspirin-tolerant asthma (ATA) and 141 healthy controls (NC). The levels of serum total IgE and SAg-specific IgE were measured using an ImmunoCAP system. Other clinical parameters were analyzed retrospectively. RESULTS: The prevalences of SEA-, SEB- and TSST-1-specific IgE in the AERD and ATA groups were significantly higher than those in the NC group (p < 0.05, respectively). The total IgE level was significantly higher in patients with AERD with high levels of SEA-specific IgE than in those with lower levels (p < 0.05), with significant positive correlations between total and SAE-specific IgE levels (p < 0.05). The PC20 methacholine level was significantly lower in patients with AERD with high levels of SEA-specific IgE, while a significantly higher eosinophil count was noted in patients with AERD with high levels of SEB-specific IgE (p < 0.05, respectively). CONCLUSIONS: Specific IgE responses to SAg may increase the serum total IgE level, airway hyperresponsiveness and eosinophil activation, leading to more severe clinical symptoms in AERD. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antibody Specificity | - |
dc.subject.MESH | Asthma, Aspirin-Induced | - |
dc.subject.MESH | Bacterial Toxins | - |
dc.subject.MESH | Enterotoxins | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Superantigens | - |
dc.title | Clinical significance of immunoglobulin E responses to staphylococcal superantigens in patients with aspirin-exacerbated respiratory disease. | - |
dc.type | Article | - |
dc.identifier.pmid | 24193355 | - |
dc.identifier.url | http://www.karger.com/?DOI=10.1159/000353976 | - |
dc.contributor.affiliatedAuthor | 유, 혜수 | - |
dc.contributor.affiliatedAuthor | 신, 유섭 | - |
dc.contributor.affiliatedAuthor | 김, 미애 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1159/000353976 | - |
dc.citation.title | International archives of allergy and immunology | - |
dc.citation.volume | 162 | - |
dc.citation.number | 4 | - |
dc.citation.date | 2013 | - |
dc.citation.startPage | 340 | - |
dc.citation.endPage | 345 | - |
dc.identifier.bibliographicCitation | International archives of allergy and immunology, 162(4). : 340-345, 2013 | - |
dc.identifier.eissn | 1423-0097 | - |
dc.relation.journalid | J010182438 | - |
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