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A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma.
DC Field | Value | Language |
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dc.contributor.author | Cho, KS | - |
dc.contributor.author | Choi, YD | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Kim, CI | - |
dc.contributor.author | Chung, BH | - |
dc.contributor.author | Seong, DH | - |
dc.contributor.author | Lee, DH | - |
dc.contributor.author | Cho, JS | - |
dc.contributor.author | Cho, IR | - |
dc.contributor.author | Hong, SJ | - |
dc.date.accessioned | 2011-01-07T01:56:42Z | - |
dc.date.available | 2011-01-07T01:56:42Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/1038 | - |
dc.description.abstract | PURPOSE: To develop a reliable prognostic model for patients with metastatic renal cell carcinoma (RCC) based on features readily available in common clinical settings.
PATIENTS AND METHODS: A total of 197 patients with RCC who underwent nephrectomy and immunotherapy from 1995 to 2004 were retrospectively reviewed. Their mean age was 55.1+/-11.8 yrs (24-83 yrs) and mean survival time from metastasis was 22.6+/-20.2 mos (3-120 mos). The impact of 24 clinicopathological features on disease specific survival was investigated. RESULTS: On univariate analysis, constitutional symptoms, sarcomatoid differentiation, tumor necrosis, multiple primary lesions, liver metastasis, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), thrombocytosis, alkaline phosphatase, hematocrit, T stage, N stage, and nuclear grade had significant influence on survival (p<0.05). Multivariate analysis revealed the following features associated with survival: sarcomatoid differentiation [hazard ratio (HR)=2.99, p<0.001], liver metastasis (HR=2.09, p=0.002), ECOG-PS (HR=1.95, p=0.005), N stage (HR=1.94, p=0.002), and number of metastatic sites (HR=1.76, p=0.003). An individual prognostic score was defined as the sum of the weight of these features. According to prognostic scores, patients could be subdivided into 3 groups: low risk (score 0), intermediate risk (score 1 or 2), and high risk (score >or= 3). CONCLUSION: A comprehensive prognostic stratification model was developed to predict survival and stratify patients for prospective clinical trials. | - |
dc.format | text/plain | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Renal Cell | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunotherapy | - |
dc.subject.MESH | Kidney Neoplasms | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Nephrectomy | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma. | - |
dc.type | Article | - |
dc.identifier.pmid | 18581596 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615339/ | - |
dc.contributor.affiliatedAuthor | 김, 세중 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.3349/ymj.2008.49.3.451 | - |
dc.citation.title | Yonsei medical journal | - |
dc.citation.volume | 49 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 451 | - |
dc.citation.endPage | 458 | - |
dc.identifier.bibliographicCitation | Yonsei medical journal, 49(3). : 451-458, 2008 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.relation.journalid | J005135796 | - |
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