Burning mouth syndrome (BMS) is defined as a chronic pain condition, characterized symptomatically by a generalized or localized burning sensation in the oral cavity without any specific mucosal lesion. Although this is not a rare disease, the etiology and effective treatment are not well established yet. Various drugs have been used in attempting to manage BMS, but there is insufficient evidence to show the effect of them. The goal of this article is to review about diagnosis, treatment, and updates current knowledge of BMS along with our experiences. Although randomized controlled studies are required to establish the treatment for patients suffering from this chronic and painful syndrome, the authors hope that this document will encourage otolaryngologist to approach to this challenging disease without fear and contribute to a better therapeutic management.