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A critical role of superoxide anion in selenite-induced mitophagic cell death.
DC Field | Value | Language |
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dc.contributor.author | Kim, EH | - |
dc.contributor.author | Choi, KS | - |
dc.date.accessioned | 2011-01-13T02:30:54Z | - |
dc.date.available | 2011-01-13T02:30:54Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/1130 | - |
dc.description.abstract | Mitochondria, which are a major source of intracellular reactive oxygen species (ROS), are extremely vulnerable to oxidative stress. We recently reported that selenite treatment of various glioma cells induced a non-apoptotic cell death accompanied by excessive mitophagy (selective autophagy of damaged mitochondria). Examination of various ROS revealed that the superoxide anion played a key role in selenite-induced mitochondrial damage, mitophagy and cell death. Treatment with superoxide generators (diquat and paraquat) was sufficient to trigger mitophagy in glioma cells. Small interfering RNA-mediated knockdown of ATG6 or ATG7 attenuated selenite-induced mitophagy and cell death, demonstrating that the mitophagic pathway contributes to selenite-induced cell death. The effect of selenite in glioma cells may thus provide an example of superoxide-mediated mitophagic cell death, i.e., cell death caused by excessive mitophagy. | - |
dc.language.iso | en | - |
dc.subject.MESH | Antineoplastic Agents | - |
dc.subject.MESH | Cell Death | - |
dc.subject.MESH | Glioma | - |
dc.subject.MESH | Herbicides | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mitochondria | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Paraquat | - |
dc.subject.MESH | Reactive Oxygen Species | - |
dc.subject.MESH | Sodium Selenite | - |
dc.subject.MESH | Superoxides | - |
dc.title | A critical role of superoxide anion in selenite-induced mitophagic cell death. | - |
dc.type | Article | - |
dc.identifier.pmid | 17952022 | - |
dc.identifier.url | http://www.landesbioscience.com/journals/auto/abstract.php?id=5119 | - |
dc.contributor.affiliatedAuthor | 최, 경숙 | - |
dc.type.local | Journal Papers | - |
dc.citation.title | Autophagy | - |
dc.citation.volume | 4 | - |
dc.citation.number | 1 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 76 | - |
dc.citation.endPage | 78 | - |
dc.identifier.bibliographicCitation | Autophagy, 4(1). : 76-78, 2008 | - |
dc.identifier.eissn | 1554-8635 | - |
dc.relation.journalid | J015548627 | - |
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