Acute Polymyositis/systemic Lupus Erythematosus Overlap Syndrome with Severe Subcutaneous Edema and Interstitial Lung Disease

Abstract

Inflammatory myopathy is characterized by symmetrical proximal muscle weakness, elevated muscle enzyme levels and favorable response to glucocorticoids therapy. Although periorbital edema is a common manifestation of inflammatory myopathy, generalized subcutaneous edema is very rare. We report here a case of a 47-year-old female patient with acute polymyositis/systemic lupus eryth-ematosus overlap syndrome with generalized subcutaneous edema and interstitial lung disease. We aggressively treat-ed the disease with high-dose glucocorticoids, intravenous immunoglobulin, and immunosuppressive agents.