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PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes.

Authors
Hwang, MN | Kim, KS | Choi, YW | Jou, I  | Yoon, S
Citation
Molecules and cells, 23(1). : 94-99, 2007
Journal Title
Molecules and cells
ISSN
1016-84780219-1032
Abstract
Suppressors of cytokine signaling (SOCS) family members are negative feedback regulators of the Jak/Stat pathway, which is an essential inflammatory signaling pathway. We investigated expression of eight members of the SOCS family in rat astrocytes, using two inflammatory stimulants, PMA and IFN-gamma. Only a few SOCS genes were induced by both stimulants, and we detected an increase in SOCS5 protein with PMA. PMA activated the Jnk, Erk, p38, and Jak/Stat signal pathways. In addition, it increased the level of activated-Stat3 resulting from tyrosine phosphorylation. A gel-shift assay showed that a protein in nuclear extracts from PMA-treated cells was able to bind to Stat binding elements. These results suggest that activated Stat3 binds to SOCS promoters and leads to their transcriptional induction.
MeSH

PMID
17464217
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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