Cited 0 times in
Elevated platelet activation in patients with chronic urticaria: a comparison between aspirin-intolerant and aspirin-tolerant groups.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Palikhe, S | - |
dc.contributor.author | Palikhe, NS | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Yoo, HS | - |
dc.contributor.author | Shin, YS | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2016-10-04T05:37:28Z | - |
dc.date.available | 2016-10-04T05:37:28Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1081-1206 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/12591 | - |
dc.description.abstract | BACKGROUND: Platelets are actively involved in immune inflammatory processes that
release inflammatory mediators. Platelet activation has been reported in various inflammatory diseases; however, few studies have described platelet involvement in chronic urticaria (CU). OBJECTIVE: To investigate platelet-activation markers, namely P2Y12 receptor and P-selectin expression, and soluble P-selectin level in patients with aspirin-intolerant CU (AICU) and aspirin-tolerant CU (ATCU). METHODS: Forty-eight patients with CU and 25 normal controls were enrolled in this study. Aspirin intolerance in patients with CU was confirmed by an oral provocation test. P2Y12 and P-selectin expressions on platelets were measured using flow cytometry; soluble P-selectin level in plasma was measured by enzyme-linked immunosorbent assay. To study the functional effects of aspirin, platelets were treated with aspirin (2 mmol/L) and the expressions of P2Y12 and P-selectin were compared between the AICU and ATCU groups. RESULTS: The expression of P2Y12 was significantly higher in patients with CU compared with controls, whereas no significant difference was noted in the expression of P-selectin level. The levels were not significantly different according to urticaria symptom score, symptom control status, and aspirin intolerance. Soluble P-selectin level was significantly higher in the AICU group than in the ATCU group compared with controls. Aspirin did not significantly suppress P2Y12 and P-selectin expressions on platelets in the AICU group, whereas significant suppression was noted in the ATCU group. CONCLUSION: These findings suggest that increased platelet activation contributes to skin inflammation in patients with AICU and those with ATCU. The functional difference of platelets in response to aspirin may contribute to persistent skin inflammation in patients with AICU. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aspirin | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Blood Platelets | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | P-Selectin | - |
dc.subject.MESH | Platelet Activation | - |
dc.subject.MESH | Receptors, Purinergic P2Y12 | - |
dc.subject.MESH | Urticaria | - |
dc.title | Elevated platelet activation in patients with chronic urticaria: a comparison between aspirin-intolerant and aspirin-tolerant groups. | - |
dc.type | Article | - |
dc.identifier.pmid | 25037610 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1081120614004128 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 유, 혜수 | - |
dc.contributor.affiliatedAuthor | 신, 유섭 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.anai.2014.06.011 | - |
dc.citation.title | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | - |
dc.citation.volume | 113 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2014 | - |
dc.citation.startPage | 276 | - |
dc.citation.endPage | 281 | - |
dc.identifier.bibliographicCitation | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(3). : 276-281, 2014 | - |
dc.identifier.eissn | 1534-4436 | - |
dc.relation.journalid | J010811206 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.