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Desmopressin alone versus desmopressin and an anticholinergic in the first-line treatment of primary monosymptomatic nocturnal enuresis: a multicenter study.

DC Field Value Language
dc.contributor.authorPark, SJ-
dc.contributor.authorPark, JM-
dc.contributor.authorPai, KS-
dc.contributor.authorHa, TS-
dc.contributor.authorLee, SD-
dc.contributor.authorBaek, M-
dc.date.accessioned2016-10-19T03:18:58Z-
dc.date.available2016-10-19T03:18:58Z-
dc.date.issued2014-
dc.identifier.issn0931-041X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12666-
dc.description.abstractBACKGROUND: The aim of this study was to compare the efficacy of combination

therapy with desmopressin and an anticholinergic to desmopressin monotherapy for

the first-line treatment of children with primary monosymptomatic nocturnal

enuresis (PMNE). METHODS: A total of 98 children with PMNE (male:female 71:27)

aged 5-16 (mean age 7.18 +/- 1.8) years were retrospectively analyzed. The

patients were divided into two groups: the monotherapy group (n = 49) was given

oral desmopressin alone, and the combination therapy group (n = 49) was given

desmopressin plus an anticholinergic (propiverine 10 mg) as a first-line

treatment. The two groups were matched according to the following criteria: age,

gender, and baseline frequency of nocturnal enuresis. The efficacy was evaluated

by International Children's Continence Society criteria at 1 and 3 months after

treatment initiation. RESULTS: The combination therapy group showed a higher rate

of complete response than the monotherapy group (20.4 vs. 6.1% at 1 month of

treatment; 46.9 vs. 22.4% at 3 months of treatment). In terms of success

(response and complete response), there was a significant difference between the

two groups after 3 months of treatment (P = 0.002). CONCLUSIONS: Our results

indicate that combination therapy with desmopressin plus an anticholinergic is

quicker and more effective than desmopressin monotherapy in reducing PMNE.
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dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCholinergic Antagonists-
dc.subject.MESHDeamino Arginine Vasopressin-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHNocturnal Enuresis-
dc.subject.MESHRetrospective Studies-
dc.titleDesmopressin alone versus desmopressin and an anticholinergic in the first-line treatment of primary monosymptomatic nocturnal enuresis: a multicenter study.-
dc.typeArticle-
dc.identifier.pmid24477979-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00467-014-2751-5-
dc.contributor.affiliatedAuthor박, 세진-
dc.contributor.affiliatedAuthor배, 기수-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00467-014-2751-5-
dc.citation.titlePediatric nephrology (Berlin, Germany)-
dc.citation.volume29-
dc.citation.number7-
dc.citation.date2014-
dc.citation.startPage1195-
dc.citation.endPage1200-
dc.identifier.bibliographicCitationPediatric nephrology (Berlin, Germany), 29(7). : 1195-1200, 2014-
dc.identifier.eissn1432-198X-
dc.relation.journalidJ00931041X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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