토끼 모델을 이용한 미세절골술 및 소파 관절 성형술 후 세포외 기질막 첨가의 유용성

Abstract

ABSTRACT i TABLE OF CONTENTS iii LIST OF FIGURES iv LIST OF TABLES v I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. In vitro 3 1. Animal Models 4 2. Monoclonal Cell Culture and Counting CFUs 5 B. In vivo 5 1. Membrane Preparation 5 2. Animal Models 5 3. Microfracture and Abrasion Arthroplasty 6 4. Gross and Histologic Analysis 7 C. Statistical Analysis 8 III. RESULTS 9 A. In vitro : Colony Frequency 9 B. In vivo : Membrane covering on Chondral defect 9 C. Gross and Histological Analysis 10 1. 4 Weeks Results 10 2. 8 Weeks Results 11 3. 12 Weeks Results 12 Ⅳ. DISCUSSION 16