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Endothelial dysfunction and hyperhomocysteinemia in Parkinson's disease: flow-mediated dilation study.

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dc.contributor.authorYoon, JH-
dc.contributor.authorLee, JS-
dc.contributor.authorYong, SW-
dc.contributor.authorHong, JM-
dc.contributor.authorLee, PH-
dc.date.accessioned2016-10-24T05:48:28Z-
dc.date.available2016-10-24T05:48:28Z-
dc.date.issued2014-
dc.identifier.issn0885-3185-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12698-
dc.description.abstractBACKGROUND: Levodopa (l-dopa) therapy in Parkinson's disease (PD) increases serum

homocysteine levels because of its metabolism via catechol O-methyltransferase,

which may lead to endothelial dysfunction. METHOD: We enrolled 40 PD patients

treated with l-dopa, 33 PD patients treated with l-dopa/entacapone, 22 untreated

PD and 30 controls, and compared the flow-mediated dilation in these subjects.

RESULTS: The flow-mediated dilation was significantly lower in PD patients with

l-dopa (6.0 +/- 1.8%) than in those with l-dopa/entacapone (7.2 +/- 1.1%, P =

0.03), untreated PD patients (7.8 +/- 1.2%, P < 0.05), and controls (8.5 +/-

2.9%, P < 0.05). The homocysteine level was significantly higher in PD patients

with l-dopa than in other groups. In a multivariate logistic regression model,

the uppermost homocysteine quartile was an independent predictor of the lowest

tertile of flow-mediated dilation (odds ratio, 6.33; 95% confidence interval,

1.61-26.65; P = 0.012). CONCLUSIONS: Our findings indicate that endothelial

dysfunction may be associated with chronic l-dopa treatment in patients with PD.
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dc.language.isoen-
dc.subject.MESHAntiparkinson Agents-
dc.subject.MESHBrachial Artery-
dc.subject.MESHCatechols-
dc.subject.MESHDilatation-
dc.subject.MESHEndothelium-
dc.subject.MESHHomocysteine-
dc.subject.MESHHyperhomocysteinemia-
dc.subject.MESHLevodopa-
dc.subject.MESHLogistic Models-
dc.subject.MESHNitriles-
dc.subject.MESHParkinson Disease-
dc.subject.MESHStatistics, Nonparametric-
dc.titleEndothelial dysfunction and hyperhomocysteinemia in Parkinson's disease: flow-mediated dilation study.-
dc.typeArticle-
dc.identifier.pmid25154960-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/mds.26005/abstract-
dc.contributor.affiliatedAuthor윤, 정한-
dc.contributor.affiliatedAuthor이, 진수-
dc.contributor.affiliatedAuthor홍, 지만-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/mds.26005-
dc.citation.titleMovement disorders-
dc.citation.volume29-
dc.citation.number12-
dc.citation.date2014-
dc.citation.startPage1551-
dc.citation.endPage1555-
dc.identifier.bibliographicCitationMovement disorders, 29(12). : 1551-1555, 2014-
dc.identifier.eissn1531-8257-
dc.relation.journalidJ008853185-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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