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Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria.
DC Field | Value | Language |
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dc.contributor.author | Bae, JS | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Ye, YM | - |
dc.contributor.author | Yoon, HJ | - |
dc.contributor.author | Suh, CH | - |
dc.contributor.author | Nahm, DH | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2011-01-26T01:29:20Z | - |
dc.date.available | 2011-01-26T01:29:20Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/1271 | - |
dc.description.abstract | BACKGROUND: Although the mechanism that underlies aspirin hypersensitivity is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU).
OBJECTIVE: We investigated whether genetic polymorphisms on the alpha-chain of the high-affinity IgE receptor (FcepsilonRIalpha) gene were associated with the AICU phenotype. METHODS: We genotyped 2 promoter polymorphisms (-344C>T and -95T>C) of FcepsilonRIalpha gene in the Korean population, and the functional effect of the -344C>T polymorphism was analyzed by using a luciferase reporter assay and an electrophoretic mobility shift assay. RESULTS: The rare allele frequency of the -344C>T polymorphism was significantly higher in the patients with AICU compared with the other subjects (P= .008 for AICU vs aspirin-tolerant chronic urticaria; P= .03 for AICU vs controls). This polymorphism was also significantly associated with total serum IgE concentrations and a higher rate of atopy in the patients with AICU (P= .01 and .05, respectively). The reporter plasmid that carried the -344T allele exhibited significantly higher promoter activity in a rat mast cell line (RBL-2H3) compared with the promoter activity of the -344C allele (P< .001). We found that transcription factor Myc-associated zinc finger protein preferentially bound the -344C promoter. Moreover, patients with AICU with the heterozygous CT genotype of the -344C>T polymorphism exhibited greater anti-IgE-mediated histamine release compared with those with the homozygous CC genotype. CONCLUSION: These results suggest that the -344C>T polymorphism of the FcepsilonRIalpha promoter may be associated with increased expression of FcepsilonRIalpha on mast cells and enhanced release of histamine. CLINICAL IMPLICATIONS: The FcepsilonRIalpha -344C>T polymorphism may contribute to the development of AICU. | - |
dc.language.iso | en | - |
dc.subject.MESH | Aspirin | - |
dc.subject.MESH | Basophils | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | DNA-Binding Proteins | - |
dc.subject.MESH | Drug Hypersensitivity | - |
dc.subject.MESH | Histamine Release | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Receptors, IgE | - |
dc.subject.MESH | Transcription Factors | - |
dc.subject.MESH | Urticaria | - |
dc.title | Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria. | - |
dc.type | Article | - |
dc.identifier.pmid | 17125826 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0091-6749(06)02120-8 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 예, 영민 | - |
dc.contributor.affiliatedAuthor | 서, 창희 | - |
dc.contributor.affiliatedAuthor | 남, 동호 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.jaci.2006.10.006 | - |
dc.citation.title | The Journal of allergy and clinical immunology | - |
dc.citation.volume | 119 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2007 | - |
dc.citation.startPage | 449 | - |
dc.citation.endPage | 456 | - |
dc.identifier.bibliographicCitation | The Journal of allergy and clinical immunology, 119(2). : 449-456, 2007 | - |
dc.identifier.eissn | 1097-6825 | - |
dc.relation.journalid | J000916749 | - |
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