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Value of endocervical margin and high-risk human papillomavirus status after conization for high-grade cervical intraepithelial neoplasia, adenocarcinoma in situ, and microinvasive carcinoma of the uterine cervix.
DC Field | Value | Language |
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dc.contributor.author | Kong, TW | - |
dc.contributor.author | Son, JH | - |
dc.contributor.author | Chang, SJ | - |
dc.contributor.author | Paek, J | - |
dc.contributor.author | Lee, Y | - |
dc.contributor.author | Ryu, HS | - |
dc.date.accessioned | 2016-11-08T05:01:30Z | - |
dc.date.available | 2016-11-08T05:01:30Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/12794 | - |
dc.description.abstract | OBJECTIVE: The aim of this study was to analyze clinico-pathologic factors and
the optimal cut-off value of high-risk human papillomavirus (HR-HPV) viral load for predicting high-grade residual/recurrent disease after the conization in cervical intraepithelial neoplasia (CIN 2-3), adenocarcinoma in situ (AIS), and microinvasive carcinoma of the uterine cervix (MICA). METHODS: We retrospectively reviewed data from 701 patients with CIN 2-3, AIS, and MICA who underwent conization between September 2003 and June 2012. Receiver-operating characteristic curve analysis was used to find out the cut-off value of HR-HPV viral load for predicting residual/recurrent disease. Clinico-pathologic variables, including resection margin and HR-HPV status, were evaluated as possible predictors of residual/recurrent disease. RESULTS: At a cut-off value of 1.16 RLU/CO for post-cone HR-HPV viral load, the sensitivity was 88.2% and the specificity was 98.3%. Multivariate analysis demonstrated that post-cone cytology (p=0.001, OR=83.808, 95% CI=6.688-1050.232), endocervical margin status (p<0.001, OR=80.478, 95% CI=7.421-872.732), and post-cone HR-HPV status (p<0.001, OR=79.660, 95% CI=8.539-743.129) were significantly associated with residual/recurrent disease. The post-cone HR-HPV positivity was observed more in the patients who showed positive endocervical margin than in the patients with positive ectocervical margin (32.6% vs. 5.3%, p=0.002). CONCLUSIONS: Follow-up using liquid based cytology in combination with HR-HPV test at 12 months after the conization, and not the early HR-HPV test, might be acceptable. Post-cone endocervical margin status combined with post-cone HR-HPV test is critical for predicting residual/recurrent disease and clinical management. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adenocarcinoma in Situ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia | - |
dc.subject.MESH | Conization | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Papillomavirus Infections | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Uterine Cervical Neoplasms | - |
dc.title | Value of endocervical margin and high-risk human papillomavirus status after conization for high-grade cervical intraepithelial neoplasia, adenocarcinoma in situ, and microinvasive carcinoma of the uterine cervix. | - |
dc.type | Article | - |
dc.identifier.pmid | 25284039 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0090825814013493 | - |
dc.contributor.affiliatedAuthor | 공, 태욱 | - |
dc.contributor.affiliatedAuthor | 장, 석준 | - |
dc.contributor.affiliatedAuthor | 백, 지흠 | - |
dc.contributor.affiliatedAuthor | 이, 용희 | - |
dc.contributor.affiliatedAuthor | 유, 희석 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.ygyno.2014.09.022 | - |
dc.citation.title | Gynecologic oncology | - |
dc.citation.volume | 135 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2014 | - |
dc.citation.startPage | 468 | - |
dc.citation.endPage | 473 | - |
dc.identifier.bibliographicCitation | Gynecologic oncology, 135(3). : 468-473, 2014 | - |
dc.identifier.eissn | 1095-6859 | - |
dc.relation.journalid | J000908258 | - |
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