Cited 0 times in Scipus Cited Count

Serum reactivity against herpes simplex virus type 1 UL48 protein in Behçet's disease patients and a Behçet's disease-like mouse model.

DC Field Value Language
dc.contributor.authorZheng, Z-
dc.contributor.authorSohn, S-
dc.contributor.authorAhn, KJ-
dc.contributor.authorBang, D-
dc.contributor.authorCho, SB-
dc.date.accessioned2017-02-06T05:51:15Z-
dc.date.available2017-02-06T05:51:15Z-
dc.date.issued2015-
dc.identifier.issn0001-5555-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13486-
dc.description.abstractHerpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet's disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated by immunoprecipitation were analysed by proteomics, and HSV UL48 was commonly found in both IgA- and IgG-reactive protein bands. Compared with controls, patients with BD and BD-like mice exhibited higher titres of IgA reacting with recombinant HSV UL48 protein. Further proteomics analysis revealed that human heat shock cognate 71 kDa protein (Hsc71) is a cross-reacting target antigen against anti-HSV UL48 antibody. In addition, our data demonstrated a very strong association between serum IgG reactivity against recombinant human Hsc71 and recombinant HSV UL48 in patients with BD. We suggest that HSV infection and impaired human Hsc71 activity may be associated with the activation of autoreactive lymphocytes.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAnimals-
dc.subject.MESHBehcet Syndrome-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCross Reactions-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHEndothelial Cells-
dc.subject.MESHFemale-
dc.subject.MESHHSC70 Heat-Shock Proteins-
dc.subject.MESHHerpesvirus 1, Human-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin A-
dc.subject.MESHImmunoglobulin G-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHMicrovessels-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRecombinant Proteins-
dc.subject.MESHViral Proteins-
dc.subject.MESHYoung Adult-
dc.titleSerum reactivity against herpes simplex virus type 1 UL48 protein in Behçet's disease patients and a Behçet's disease-like mouse model.-
dc.typeArticle-
dc.identifier.pmid25916670-
dc.identifier.urlhttps://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2127-
dc.contributor.affiliatedAuthor손, 성향-
dc.type.localJournal Papers-
dc.identifier.doi10.2340/00015555-2127-
dc.citation.titleActa dermato-venereologica-
dc.citation.volume95-
dc.citation.number8-
dc.citation.date2015-
dc.citation.startPage952-
dc.citation.endPage958-
dc.identifier.bibliographicCitationActa dermato-venereologica, 95(8). : 952-958, 2015-
dc.identifier.eissn1651-2057-
dc.relation.journalidJ000015555-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse