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Sirt1 Regulates Microtubule Dynamics Through Negative Regulation of Plk1 in Mitosis.

Authors
Kim, JJ | Gil, NY | Zhang, XH | Chun, KH | Fang, G | Kim, J | Cho, H  | Jang, CY | Cha, HJ
Citation
Journal of cellular biochemistry, 116(9). : 1888-1897, 2015
Journal Title
Journal of cellular biochemistry
ISSN
0730-23121097-4644
Abstract
Although loss of Sirt1 leads to chromosome aneuploidy, which accounts for higher tumor susceptibility, the molecular mechanisms remain unclear. Herein, we demonstrate that Sirt1 directly regulates Plk1, of which activity is critical for mitotic progression and spindle dynamics. Depletion or inhibition of Sirt1 significantly perturbs the formation of the mitotic spindle, leading to defective chromosome segregation. Elevated depolymerization of the mitotic spindle following loss of Sirt1 was associated with the deregulation of Plk1 activity. Thus, we conclude that Sirt1 may contribute to a mitotic regulator that controls spindle dynamics through Plk1 activity, resulting in fine-tuning of Plk1 dependent microtubule dynamics.
MeSH

DOI
10.1002/jcb.25144
PMID
25737075
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Ajou Authors
조, 혜성
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