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α-Mangostin induces G1 cell cycle arrest in HCT116 cells through p38MAPK-p16INK4a pathway

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dc.contributor.authorKorm, S-
dc.contributor.authorJeong, HC-
dc.contributor.authorKwon, OS-
dc.contributor.authorPark, JR-
dc.contributor.authorCho, H-
dc.contributor.authorKim, YM-
dc.contributor.authorChin, YW-
dc.contributor.authorCha, HJ-
dc.date.accessioned2017-03-16T02:37:01Z-
dc.date.available2017-03-16T02:37:01Z-
dc.date.issued2015-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13555-
dc.description.abstractα-Mangostin (α-MG), one of the active substances in Garcinia mangostana, has been shown to exhibit anti-cancer effects in various cancer cell types. α-MG treatment induces G1 arrest in cancer cell models through the induction of cyclin-dependent kinase inhibitors (CDKIs) and the subsequent loss of CDK activity. However, outside its role in the p53-p21CIP1 axis, the precise molecular mechanisms underlying the effect of α-MG on cell cycle arrest remain unclear. In this study, we observed that α-MG inhibits the proliferation of HCT116 cells in a dose-dependent manner. Interestingly, although the loss of p53 rescued the α-MG effect on cell cycle arrest, in agreement with previous reports, p21Cip1 expression was only marginally delayed in the absence of p53 after α-MG treatment. Instead, we found that the activation of p38 mitogen activated protein kinase (MAPK) and the subsequent downregulation of Bmi-1 also contributed to the induction of p16Ink4a, which is responsible for G1 arrest upon α-MG treatment. These findings indicate that α-MG exerts cytostatic effects on colon cancer cells by inducing G1 arrest via the p38MAPK-p16INK4a axis.-
dc.language.isoen-
dc.titleα-Mangostin induces G1 cell cycle arrest in HCT116 cells through p38MAPK-p16INK4a pathway-
dc.typeArticle-
dc.identifier.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/c5ra00780a#!divAbstract-
dc.contributor.affiliatedAuthor조, 혜성-
dc.type.localJournal Papers-
dc.citation.titleRSC advances-
dc.citation.volume2015-
dc.citation.number44-
dc.citation.date2015-
dc.citation.startPage34752-
dc.citation.endPage34760-
dc.identifier.bibliographicCitationRSC advances, 2015(44). : 34752-34760, 2015-
dc.identifier.eissn2046-2069-
dc.relation.journalidJ020462069-
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Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
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