Cited 0 times in Scipus Cited Count

Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist's View.

DC Field Value Language
dc.contributor.authorNahm, DH-
dc.date.accessioned2017-03-31T05:08:06Z-
dc.date.available2017-03-31T05:08:06Z-
dc.date.issued2015-
dc.identifier.issn1013-9087-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13722-
dc.description.abstractThe current standard medical therapy for atopic dermatitis (AD) mainly focuses on symptomatic relief by controlling skin inflammation with topical corticosteroids and/or topical calcineurin inhibitors. However, the clinical efficacy of pharmacological therapy is often disappointing to both patients and physicians. The terminology of AD contains a historical meaning of eczematous dermatitis caused by hypersensitivity reaction to environmental inhalant or food allergen. Complex interrelationships among genetic abnormalities, environmental triggers, skin barrier defects, and immune dysfunction resulting in a vicious domino-circle seem to be involved in the development and maintenance of AD. In the viewpoint of AD as an allergic disease, complete avoidance of clinically relevant allergen or induction of specific immune tolerance through administrations of allergen (allergen immunotherapy) can provide clinical remission by breaking the vicious domino-circle maintaining a chronic disease state. In recent clinical studies, monoclonal antibodies including the anti-interleukin-4 receptor antibody and anti-B cell antibody induced significant clinical improvements in patients with AD. The detailed characteristics of immune dysfunction are heterogeneous among patients with AD. Therefore, a personalized combination of immunomodulatory therapies to reduce hypersensitivity (allergen immunotherapy) and correct immune dysfunction (monoclonal antibody therapy) could be a reasonable therapeutic approach for patients with AD. Future immunomodulatory therapies for AD should be developed to achieve long-term treatment-free clinical remission by induction of immune tolerance.-
dc.language.isoen-
dc.titlePersonalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist's View.-
dc.typeArticle-
dc.identifier.pmid26273148-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530142/-
dc.subject.keywordAllergens-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordHypersensitivity-
dc.subject.keywordImmunomodulation-
dc.subject.keywordTherapeutics-
dc.contributor.affiliatedAuthor남, 동호-
dc.type.localJournal Papers-
dc.identifier.doi10.5021/ad.2015.27.4.355-
dc.citation.titleAnnals of dermatology-
dc.citation.volume27-
dc.citation.number4-
dc.citation.date2015-
dc.citation.startPage355-
dc.citation.endPage363-
dc.identifier.bibliographicCitationAnnals of dermatology, 27(4). : 355-363, 2015-
dc.identifier.eissn2005-3894-
dc.relation.journalidJ010139087-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Files in This Item:
26273148.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse