Cited 0 times in Scipus Cited Count

Multinational Randomized Phase III Trial With or Without Consolidation Chemotherapy Using Docetaxel and Cisplatin After Concurrent Chemoradiation in Inoperable Stage III Non-Small-Cell Lung Cancer: KCSG-LU05-04.

DC Field Value Language
dc.contributor.authorAhn, JS-
dc.contributor.authorAhn, YC-
dc.contributor.authorKim, JH-
dc.contributor.authorLee, CG-
dc.contributor.authorCho, EK-
dc.contributor.authorLee, KC-
dc.contributor.authorChen, M-
dc.contributor.authorKim, DW-
dc.contributor.authorKim, HK-
dc.contributor.authorMin, YJ-
dc.contributor.authorKang, JH-
dc.contributor.authorChoi, JH-
dc.contributor.authorKim, SW-
dc.contributor.authorZhu, G-
dc.contributor.authorWu, YL-
dc.contributor.authorKim, SR-
dc.contributor.authorLee, KH-
dc.contributor.authorSong, HS-
dc.contributor.authorChoi, YL-
dc.contributor.authorSun, JM-
dc.contributor.authorJung, SH-
dc.contributor.authorAhn, MJ-
dc.contributor.authorPark, K-
dc.date.accessioned2017-06-05T06:23:52Z-
dc.date.available2017-06-05T06:23:52Z-
dc.date.issued2015-
dc.identifier.issn0732-183X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14035-
dc.description.abstractPURPOSE: To determine the efficacy of consolidation chemotherapy (CC) with docetaxel and cisplatin (DP) after concurrent chemoradiotherapy (CCRT) with the same agents in locally advanced non-small-cell lung cancer (LA-NSCLC).

PATIENT AND METHODS: Patients were randomly assigned to either CCRT alone (observation arm) or CCRT followed by CC (consolidation arm). CCRT with docetaxel (20 mg/m(2)) and cisplatin (20 mg/m(2)) was administered every week for 6 weeks with a total dose of 66 Gy of thoracic radiotherapy in 33 fractions. In the consolidation arm, patients were further treated with three cycles of DP (35 mg/m(2) each on days 1 and 8, every 3 weeks). The primary end point was 40% improvement in progression-free survival (PFS) compared with observation.

RESULTS: From October 2005 to April 2011, 437 patients were randomly assigned. Seventeen patients did not start CCRT as a result of consent withdrawal or ineligibility reasons after random assignment, leaving 420 patients for this analysis (n = 211 for observation; n = 209 for consolidation). Patient characteristics were similar in both arms. In the consolidation arm, 143 patients (68%) received CC, of whom 88 (62%) completed three planned cycles. The median PFS was 8.1 months in the observation arm and 9.1 months in the consolidation arm (hazard ratio, 0.91; 95% CI, 0.73 to 1.12; P = .36). Median overall survival times were 20.6 and 21.8 months in the observation and consolidation arms, respectively (HR, 0.91; 95% CI, 0.72 to 1.25; P = .44).

CONCLUSION: CC with DP after CCRT with weekly DP in LA-NSCLC failed to further prolong PFS. CCRT alone should remain the standard of care.

TRIAL REGISTRATION: ClinicalTrials.gov NCT00326378.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHCisplatin-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHTaxoids-
dc.titleMultinational Randomized Phase III Trial With or Without Consolidation Chemotherapy Using Docetaxel and Cisplatin After Concurrent Chemoradiation in Inoperable Stage III Non-Small-Cell Lung Cancer: KCSG-LU05-04.-
dc.typeArticle-
dc.identifier.pmid26150444-
dc.identifier.urlhttp://ascopubs.org/doi/abs/10.1200/JCO.2014.60.0130?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed-
dc.contributor.affiliatedAuthor최, 진혁-
dc.type.localJournal Papers-
dc.identifier.doi10.1200/JCO.2014.60.0130-
dc.citation.titleJournal of clinical oncology-
dc.citation.volume33-
dc.citation.number24-
dc.citation.date2015-
dc.citation.startPage2660-
dc.citation.endPage2666-
dc.identifier.bibliographicCitationJournal of clinical oncology, 33(24). : 2660-2666, 2015-
dc.identifier.eissn1527-7755-
dc.relation.journalidJ00732183X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse