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n-Butanol Extract of Mulberry Leaves Suppresses LPS-induced Inflammatory Cytokines and Modulates Osteogenic Differentiation in Periodontal Ligament Cells

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dc.contributor.author최, 정이-
dc.contributor.author김, 대근-
dc.contributor.author김, 은희-
dc.contributor.author이, 정근-
dc.date.accessioned2017-06-09T02:50:14Z-
dc.date.available2017-06-09T02:50:14Z-
dc.date.issued2015-
dc.identifier.issn0253-3073-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14078-
dc.description.abstractPeriodontitis is a chronic inflammatory disease that is known to have the characteristics of destructed periodontal tissue. Anti-oxidant and anti-inflammatory effects of mulberry leaves in periodontal tissue is not well known until now. We investigated the effects of n-butanol extract of mulberry leaves on the lipopolysaccharide (LPS)-induced proinflammatory cytokines, such as IL-1β, IL-6, IL-8 and modulates osteogenic differentiation in periodontal ligament cells. The expression levels of Runx2, ALP and mRNA were increased by n-butanol extract of mulberry leaves at the concentration of 100 μg/ml in periodontal ligament cells. n-Butanol extract of mulberry leaves extract reduced the range of pathophysiological processes, such as inflammation and increase in the level of osteogenic-related genes. These findings suggest that n-butanol extract of mulberry leaves has therapeutic effects on periodontitis and periodontal tissue regeneartion.-
dc.language.isoko-
dc.titlen-Butanol Extract of Mulberry Leaves Suppresses LPS-induced Inflammatory Cytokines and Modulates Osteogenic Differentiation in Periodontal Ligament Cells-
dc.title.alternative뽕잎 n-부탄올 추출물의 치주인대세포에서 LPS로 유도된 염증성 사이토카인의 억제와 골 형성 분화 조절-
dc.typeArticle-
dc.identifier.urlhttp://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=3384777#-
dc.subject.keywordMelberry Leaves-
dc.subject.keywordLPS-
dc.subject.keywordInflammation-
dc.subject.keywordPeriodontal Ligament cells-
dc.subject.keywordCell differentiation-
dc.contributor.affiliatedAuthor이, 정근-
dc.type.localJournal Papers-
dc.citation.titleKorean journal of pharmacognosy-
dc.citation.volume46-
dc.citation.number4-
dc.citation.date2015-
dc.citation.startPage309-
dc.citation.endPage314-
dc.identifier.bibliographicCitationKorean journal of pharmacognosy, 46(4). : 309-314, 2015-
dc.identifier.eissn2288-9299-
dc.relation.journalidJ002533073-
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Journal Papers > School of Medicine / Graduate School of Medicine > Dentistry
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