Cited 0 times in Scipus Cited Count

A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis

DC Field Value Language
dc.contributor.authorKim, SJ-
dc.contributor.authorYoon, DH-
dc.contributor.authorJaccard, A-
dc.contributor.authorChng, WJ-
dc.contributor.authorLim, ST-
dc.contributor.authorHong, H-
dc.contributor.authorPark, Y-
dc.contributor.authorChang, KM-
dc.contributor.authorMaeda, Y-
dc.contributor.authorIshida, F-
dc.contributor.authorShin, DY-
dc.contributor.authorKim, JS-
dc.contributor.authorJeong, SH-
dc.contributor.authorYang, DH-
dc.contributor.authorJo, JC-
dc.contributor.authorLee, GW-
dc.contributor.authorChoi, CW-
dc.contributor.authorLee, WS-
dc.contributor.authorChen, TY-
dc.contributor.authorKim, K-
dc.contributor.authorJung, SH-
dc.contributor.authorMurayama, T-
dc.contributor.authorOki, Y-
dc.contributor.authorAdvani, R-
dc.contributor.authord'Amore, F-
dc.contributor.authorSchmitz, N-
dc.contributor.authorSuh, C-
dc.contributor.authorSuzuki, R-
dc.contributor.authorKwong, YL-
dc.contributor.authorLin, TY-
dc.contributor.authorKim, WS-
dc.date.accessioned2018-05-04T00:23:36Z-
dc.date.available2018-05-04T00:23:36Z-
dc.date.issued2016-
dc.identifier.issn1470-2045-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14739-
dc.description.abstractBACKGROUND: The clinical outcome of extranodal natural killer T-cell lymphoma (ENKTL) has improved substantially as a result of new treatment strategies with non-anthracycline-based chemotherapies and upfront use of concurrent chemoradiotherapy or radiotherapy. A new prognostic model based on the outcomes obtained with these contemporary treatments was warranted. METHODS: We did a retrospective study of patients with newly diagnosed ENKTL without any previous treatment history for the disease who were given non-anthracycline-based chemotherapies with or without upfront concurrent chemoradiotherapy or radiotherapy with curative intent. A prognostic model to predict overall survival and progression-free survival on the basis of pretreatment clinical and laboratory characteristics was developed by filling a multivariable model on the basis of the dataset with complete data for the selected risk factors for an unbiased prediction model. The final model was applied to the patients who had complete data for the selected risk factors. We did a validation analysis of the prognostic model in an independent cohort. FINDINGS: We did multivariate analyses of 527 patients who were included from 38 hospitals in 11 countries in the training cohort. Analyses showed that age greater than 60 years, stage III or IV disease, distant lymph-node involvement, and non-nasal type disease were significantly associated with overall survival and progression-free survival. We used these data as the basis for the prognostic index of natural killer lymphoma (PINK), in which patients are stratified into low-risk (no risk factors), intermediate-risk (one risk factor), or high-risk (two or more risk factors) groups, which were associated with 3-year overall survival of 81% (95% CI 75-86), 62% (55-70), and 25% (20-34), respectively. In the 328 patients with data for Epstein-Barr virus DNA, a detectable viral DNA titre was an independent prognostic factor for overall survival. When these data were added to PINK as the basis for another prognostic index (PINK-E)-which had similar low-risk (zero or one risk factor), intermediate-risk (two risk factors), and high-risk (three or more risk factors) categories-significant associations with overall survival were noted (81% [95% CI 75-87%], 55% (44-66), and 28% (18-40%), respectively). These results were validated and confirmed in an independent cohort, although the PINK-E model was only significantly associated with the high-risk group compared with the low-risk group. INTERPRETATION: PINK and PINK-E are new prognostic models that can be used to develop risk-adapted treatment approaches for patients with ENKTL being treated in the contemporary era of non-anthracycline-based therapy. FUNDING: Samsung Biomedical Research Institute.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnthracyclines-
dc.subject.MESHAntineoplastic Agents-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHCohort Studies-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHConfidence Intervals-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKiller Cells, Natural-
dc.subject.MESHLymphoma, Extranodal NK-T-Cell-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleA prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis-
dc.typeArticle-
dc.identifier.pmid26873565-
dc.contributor.affiliatedAuthor정, 성현-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/S1470-2045(15)00533-1-
dc.citation.titleThe Lancet. Oncology-
dc.citation.volume17-
dc.citation.number3-
dc.citation.date2016-
dc.citation.startPage389-
dc.citation.endPage400-
dc.identifier.bibliographicCitationThe Lancet. Oncology, 17(3). : 389-400, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1474-5488-
dc.relation.journalidJ014702045-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse