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Basal-prandial versus premixed insulin in patients with type 2 diabetes requiring insulin intensification after basal insulin optimization: A 24-week randomized non-inferiority trial

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dc.contributor.authorJin, SM-
dc.contributor.authorKim, JH-
dc.contributor.authorMin, KW-
dc.contributor.authorLee, JH-
dc.contributor.authorAhn, KJ-
dc.contributor.authorPark, JH-
dc.contributor.authorJang, HC-
dc.contributor.authorPark, SW-
dc.contributor.authorLee, KW-
dc.contributor.authorWon, KC-
dc.contributor.authorKim, YI-
dc.contributor.authorChung, CH-
dc.contributor.authorPark, TS-
dc.contributor.authorLee, JH-
dc.contributor.authorLee, MK-
dc.date.accessioned2018-05-04T00:23:58Z-
dc.date.available2018-05-04T00:23:58Z-
dc.date.issued2016-
dc.identifier.issn1753-0393-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14784-
dc.description.abstractBACKGROUND: The aim of the present 24-week multicentre randomized non-inferiority trial was to compare the efficacy and safety of two insulin intensification strategies in uncontrolled type 2 diabetes despite optimized basal insulin therapy. METHODS: Patients with fasting plasma glucose (FPG) <130 mg/dL and HbA1c 7.0%-10.0% while on insulin glargine were randomized to a basal-prandial group (stepwise addition of insulin glulisine) or a premixed insulin group (insulin aspart/insulin aspart protamine 30/70 starting with 6 IU twice daily). The primary endpoint was the change in HbA1c after 24 weeks (non-inferiority margin 0.4%). RESULTS: At Week 24, the adjusted mean change from baseline HbA1c was -0.94 +/- 0.09% and -1.04 +/- 0.09% in basal-prandial and premixed insulin groups, respectively, with a mean difference of -0.09% (95% confidence interval [CI] -0.35, 0.16). A lower rate of hypoglycemia with a similar reduction in HbA1c was observed during stabilization of the total daily insulin dose in the premixed insulin group (Weeks 0-12). After stabilization of the total daily insulin dose, the rate of hypoglycemia and the total daily insulin dose were similar in the two groups. CONCLUSIONS: The efficacy and safety of the two intensifying regimens were similar after stabilization of the total daily insulin dose when oral agents were maintained. Starting with a lower total daily insulin dose with a gradual change in the treatment regimen was helpful in reducing the rate of hypoglycemia during initial stabilization of the total daily insulin dose.-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHBlood Glucose-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHFemale-
dc.subject.MESHGlycated Hemoglobin A-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemia-
dc.subject.MESHHypoglycemic Agents-
dc.subject.MESHInsulin-
dc.subject.MESHInsulin Aspart-
dc.subject.MESHInsulin Glargine-
dc.subject.MESHInsulin Lispro-
dc.subject.MESHMale-
dc.subject.MESHTime Factors-
dc.titleBasal-prandial versus premixed insulin in patients with type 2 diabetes requiring insulin intensification after basal insulin optimization: A 24-week randomized non-inferiority trial-
dc.typeArticle-
dc.identifier.pmid25952532-
dc.contributor.affiliatedAuthor이, 관우-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/1753-0407.12312-
dc.citation.titleJournal of diabetes-
dc.citation.volume8-
dc.citation.number3-
dc.citation.date2016-
dc.citation.startPage405-
dc.citation.endPage413-
dc.identifier.bibliographicCitationJournal of diabetes, 8(3). : 405-413, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1753-0407-
dc.relation.journalidJ017530393-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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