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Management of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System: A Korean Gynecologic-Oncology Group Study

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dc.contributor.authorKim, MK-
dc.contributor.authorSeong, SJ-
dc.contributor.authorKim, JW-
dc.contributor.authorJeon, S-
dc.contributor.authorChoi, HS-
dc.contributor.authorLee, IH-
dc.contributor.authorLee, JH-
dc.contributor.authorJu, W-
dc.contributor.authorSong, ES-
dc.contributor.authorPark, H-
dc.contributor.authorRyu, HS-
dc.contributor.authorLee, C-
dc.contributor.authorKang, SB-
dc.date.accessioned2018-05-04T00:25:38Z-
dc.date.available2018-05-04T00:25:38Z-
dc.date.issued2016-
dc.identifier.issn1048-891X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15026-
dc.description.abstractOBJECTIVE: The aim of the study was to evaluate the efficacy of the levonorgestrel intrauterine system (LNG-IUS) for treatment of endometrial hyperplasia (EH). METHODS: A prospective multicenter study was conducted from November 2010 to March 2014. Patients with histologically confirmed EH were treated with LNG-IUS. At 3, 6, and 9 months after LNG-IUS insertion, follow-up endometrial aspiration biopsies with the LNG-IUS in the uterus were undertaken. At the 12th month of follow-up, endometrial tissues were obtained via 2 methods: endometrial aspiration biopsy with the LNG-IUS in the uterus, followed by dilatation and curettage (D&C) after LNG-IUS removal. The primary outcome was the regression rate at 12 months after LNG-IUS insertion, and the secondary outcome was the consistency of the results between the endometrial aspiration biopsy and the D&C. RESULTS: The study population comprised 75 patients, including 37 with simple hyperplasia without atypia: 3 with atypical simple hyperplasia: 23 with complex hyperplasia without atypia, and 12 with atypical complex hyperplasia. Of these patients treated with the LNG-IUS, 38 (50.7%) were followed up at 12 months after LNG-IUS insertion. The complete regression rate at 12 months was 94.7% (36/38): 100% (6/6) of patients with atypical EH and 93.7% (30/32) with EH without atypia. In all of the cases (100%, 36/36), patients achieved complete regression within 3 months of LNG-IUS insertion. A comparison of the pathologic results from endometrial aspiration biopsy and D&C was carried out for 15 patients. In the histologic results by endometrial aspiration biopsy, 14 patients were diagnosed as "normal endometrium" and 1 as "insufficient tissue for pathologic evaluation." Among the 14 cases of normal endometrium by endometrial aspiration biopsy, 1 was diagnosed as "residual EH" by D&C, and the 1 case with insufficient tissue was diagnosed as normal endometrium by D&C. CONCLUSIONS: Levonorgestrel intrauterine system is an effective and favorable method for treatment of EH.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHContraceptive Agents, Female-
dc.subject.MESHDisease Management-
dc.subject.MESHEndometrial Hyperplasia-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIntrauterine Devices, Medicated-
dc.subject.MESHLevonorgestrel-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHYoung Adult-
dc.titleManagement of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System: A Korean Gynecologic-Oncology Group Study-
dc.typeArticle-
dc.identifier.pmid26905333-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/IGC.0000000000000669-
dc.citation.titleInternational journal of gynecological cancer-
dc.citation.volume26-
dc.citation.number4-
dc.citation.date2016-
dc.citation.startPage711-
dc.citation.endPage715-
dc.identifier.bibliographicCitationInternational journal of gynecological cancer, 26(4). : 711-715, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1525-1438-
dc.relation.journalidJ01048891X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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