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Significance of the DNA-Histone Complex Level as a Predictor of Major Adverse Cardiovascular Events in Hemodialysis Patients: The Effect of Uremic Toxin on DNA-Histone Complex Formation

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dc.contributor.authorJeong, JC-
dc.contributor.authorKim, JE-
dc.contributor.authorGu, JY-
dc.contributor.authorYoo, HJ-
dc.contributor.authorRyu, JW-
dc.contributor.authorKim, DK-
dc.contributor.authorJoo, KW-
dc.contributor.authorKim, HK-
dc.date.accessioned2018-05-04T00:26:33Z-
dc.date.available2018-05-04T00:26:33Z-
dc.date.issued2016-
dc.identifier.issn0253-5068-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15153-
dc.description.abstractBACKGROUND: Neutrophils can release the DNA-histone complex into circulation following exposure to inflammatory stimuli. This prospective study investigated whether the DNA-histone complex and other biomarkers could predict major cardiovascular adverse events (MACEs) in hemodialysis (HD) patients. METHODS: The levels of circulating DNA-histone complexes, cell-free DNA, interleukin (IL)-6, and neutrophil elastase were measured in 60 HD patients and 28 healthy controls. MACE was assessed at 24 months. Uremic toxin-induced neutrophil released contents were measured in vitro. RESULTS: Compared with controls, HD patients showed higher levels of DNA-histone complexes and IL-6. The DNA-histone complex level was inversely associated with the Kt/V. In a multivariable Cox analysis, the high level of DNA-histone complexes was a significant independent predictor of MACE. The uremic toxins induced DNA-histone complex formation in normal neutrophils in vitro. CONCLUSION: The DNA-histone complex is a potentially useful marker to predict MACE in HD patients. Uremic toxins induced DNA-histone complex formation in vitro.-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers-
dc.subject.MESHCardiovascular Diseases-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDNA-
dc.subject.MESHFemale-
dc.subject.MESHHistones-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-6-
dc.subject.MESHKidney Failure, Chronic-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeutrophil Activation-
dc.subject.MESHNeutrophils-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRenal Dialysis-
dc.subject.MESHUremia-
dc.titleSignificance of the DNA-Histone Complex Level as a Predictor of Major Adverse Cardiovascular Events in Hemodialysis Patients: The Effect of Uremic Toxin on DNA-Histone Complex Formation-
dc.typeArticle-
dc.identifier.pmid26517236-
dc.contributor.affiliatedAuthor정, 종철-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000440974-
dc.citation.titleBlood purification-
dc.citation.volume41-
dc.citation.number1-3-
dc.citation.date2016-
dc.citation.startPage64-
dc.citation.endPage71-
dc.identifier.bibliographicCitationBlood purification, 41(1-3). : 64-71, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1421-9735-
dc.relation.journalidJ002535068-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Nephrology
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