A cross-sectional study of the association between adipokine levels and bone mineral density according to obesity and menopausal status in Korean women

Abstract

Results regarding the association between adipokine levels and bone mineral density (BMD) have been inconsistent: the effects of sex, menopause, and central obesity remain unknown. We evaluated the association between serum leptin, adiponectin, and high-molecular-weight (HMW) adiponectin levels and BMD according to menopause and central obesity status in Korean women. This cross-sectional study comprised 255 women undergoing examinations at the CHA Bundang Medical Center. Participants were divided according to menopause, and central obesity status. We measured serum adipokine levels and BMD using an enzyme-linked immunosorbent assay and dual-energy X-ray absorptiometry, respectively. After adjusting for age, body mass index, alkaline phosphatase levels and the Homeostasis Model Assessment index, leptin levels were negatively associated with non-vertebral BMD (total hip, beta = -0.576, P = 0.006: femoral neck, beta = -0.608, P = 0.007) in postmenopausal women without central obesity. Among women without central obesity, HMW adiponectin levels were positively associated with total hip BMD (beta = 0.240, P = 0.010) in premenopausal women but negatively associated with BMD (lumbar, beta = -0.436, P = 0.012: femoral neck, beta = -0.468, P = 0.007) in postmenopausal women. Thus, the association between adipokine levels and BMD varies according to the menopause and central obesity status.