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Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches
DC Field | Value | Language |
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dc.contributor.author | Lee, J | - |
dc.contributor.author | Ji, SC | - |
dc.contributor.author | Kim, B | - |
dc.contributor.author | Yi, S | - |
dc.contributor.author | Shin, KH | - |
dc.contributor.author | Cho, JY | - |
dc.contributor.author | Lim, KS | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Yoon, SH | - |
dc.contributor.author | Chung, JY | - |
dc.contributor.author | Yu, KS | - |
dc.contributor.author | Park, HS | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Jang, IJ | - |
dc.date.accessioned | 2018-07-27T00:52:12Z | - |
dc.date.available | 2018-07-27T00:52:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1752-8054 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/15586 | - |
dc.description.abstract | To explore potential biomarkers for amoxicillin/clavulanate-induced liver injury (AC-DILI), we conducted a clinical trial in 32 healthy subjects based on multi-omics approaches. Every subject was administered amoxicillin/clavulanate for 14 days. The liver-specific microRNA-122 (miR-122) level increased prior to and correlated well with the observed alanine aminotransferase (ALT) level increase. This result indicates its potential as a sensitive early marker for AC-DILI. We also identified urinary metabolites, such as azelaic acid and 7-methylxanthine, with levels that significantly differed among the groups classified by ALT elevation level on day 8 after drug administration (P < 0.05). Lymphocyte proliferation in response to the drug was also observed. These findings demonstrate sequential changes in the process of AC-DILI, including metabolic changes, increased miR-122 level, increased liver enzyme activity, and enhanced lymphocyte proliferation after drug administration. In conclusion, this study provides potential biomarkers for AC-DILI based on currently known mechanisms using comprehensive multi-omics approaches. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alanine Transaminase | - |
dc.subject.MESH | Amoxicillin | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Chemical and Drug Induced Liver Injury | - |
dc.subject.MESH | Clavulanic Acid | - |
dc.subject.MESH | Demography | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphocytes | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolome | - |
dc.subject.MESH | MicroRNAs | - |
dc.subject.MESH | Time Factors | - |
dc.title | Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches | - |
dc.type | Article | - |
dc.identifier.pmid | 27785887 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421739/ | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/cts.12425 | - |
dc.citation.title | Clinical and translational science | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2017 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 171 | - |
dc.identifier.bibliographicCitation | Clinical and translational science, 10(3). : 163-171, 2017 | - |
dc.identifier.eissn | 1752-8062 | - |
dc.relation.journalid | J017528054 | - |
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