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Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches

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dc.contributor.authorLee, J-
dc.contributor.authorJi, SC-
dc.contributor.authorKim, B-
dc.contributor.authorYi, S-
dc.contributor.authorShin, KH-
dc.contributor.authorCho, JY-
dc.contributor.authorLim, KS-
dc.contributor.authorLee, SH-
dc.contributor.authorYoon, SH-
dc.contributor.authorChung, JY-
dc.contributor.authorYu, KS-
dc.contributor.authorPark, HS-
dc.contributor.authorKim, SH-
dc.contributor.authorJang, IJ-
dc.date.accessioned2018-07-27T00:52:12Z-
dc.date.available2018-07-27T00:52:12Z-
dc.date.issued2017-
dc.identifier.issn1752-8054-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15586-
dc.description.abstractTo explore potential biomarkers for amoxicillin/clavulanate-induced liver injury (AC-DILI), we conducted a clinical trial in 32 healthy subjects based on multi-omics approaches. Every subject was administered amoxicillin/clavulanate for 14 days. The liver-specific microRNA-122 (miR-122) level increased prior to and correlated well with the observed alanine aminotransferase (ALT) level increase. This result indicates its potential as a sensitive early marker for AC-DILI. We also identified urinary metabolites, such as azelaic acid and 7-methylxanthine, with levels that significantly differed among the groups classified by ALT elevation level on day 8 after drug administration (P < 0.05). Lymphocyte proliferation in response to the drug was also observed. These findings demonstrate sequential changes in the process of AC-DILI, including metabolic changes, increased miR-122 level, increased liver enzyme activity, and enhanced lymphocyte proliferation after drug administration. In conclusion, this study provides potential biomarkers for AC-DILI based on currently known mechanisms using comprehensive multi-omics approaches.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAlanine Transaminase-
dc.subject.MESHAmoxicillin-
dc.subject.MESHBiomarkers-
dc.subject.MESHCell Proliferation-
dc.subject.MESHChemical and Drug Induced Liver Injury-
dc.subject.MESHClavulanic Acid-
dc.subject.MESHDemography-
dc.subject.MESHHumans-
dc.subject.MESHLymphocytes-
dc.subject.MESHMale-
dc.subject.MESHMetabolome-
dc.subject.MESHMicroRNAs-
dc.subject.MESHTime Factors-
dc.titleExploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches-
dc.typeArticle-
dc.identifier.pmid27785887-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421739/-
dc.contributor.affiliatedAuthor박, 해심-
dc.contributor.affiliatedAuthor김, 승현-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/cts.12425-
dc.citation.titleClinical and translational science-
dc.citation.volume10-
dc.citation.number3-
dc.citation.date2017-
dc.citation.startPage163-
dc.citation.endPage171-
dc.identifier.bibliographicCitationClinical and translational science, 10(3). : 163-171, 2017-
dc.identifier.eissn1752-8062-
dc.relation.journalidJ017528054-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Hospital > Clinical Trial Center
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