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Clinical usefulness of F-18 FDG PET in lymphoepithelioma-like gastric carcinoma

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dc.contributor.authorPark, S-
dc.contributor.authorLee, D-
dc.contributor.authorLee, KM-
dc.contributor.authorHan, SU-
dc.contributor.authorLee, JH-
dc.contributor.authorLee, SJ-
dc.contributor.authorAn, YS-
dc.contributor.authorYoon, JK-
dc.date.accessioned2018-08-24T01:48:42Z-
dc.date.available2018-08-24T01:48:42Z-
dc.date.issued2017-
dc.identifier.issn0720-048X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15877-
dc.description.abstractPURPOSE: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric cancer. We evaluated the clinical usefulness of F-18 FDG positron emission tomography/computed tomography (PET/CT) in LELC of stomach.
MATERIALS AND METHODS: A total of 28 patients (mean age=59years) who underwent preoperative F-18 FDG PET/CT were enrolled retrospectively. Nine patients underwent follow-up F-18 FDG PET/CT. Pathologic information was obtained through gastrectomy and the association with Epstein-Barr virus (EBV) was investigated in 26 patients.
RESULTS: PET/CT detected 85.0% (17/20) of advanced gastric cancers (AGC) and 12.5% (1/8) of early gastric cancers (EGC). Most tumors (23/26, 88.5%) were EBV-associated. The maximum standardized uptake value of FDG-avid tumors was 7.5+/-3.0. The sensitivity and specificity of PET/CT for the presence of lymph node metastasis was 47.8% (11/23) and 100.0% (13/13), respectively. PET/CT also detected a hepatic sarcomatoid carcinoma in one patient. The specificity of PET/CT for distant metastasis or second malignancy was 96.3%. Follow-up PET/CT detected malignant lesions in 3 of 9 patients: a liver metastasis, recurrent hepatic sarcomatoid carcinomas and a metachronous cholangiocarcinoma. PET/CT correctly excluded recurrence in the rest of the patients (6/6). The sensitivity and specificity of PET/CT for detecting recurrence or second malignancy was 100% and 100%, respectively.
CONCLUSION: F-18 FDG PET/CT would be a useful tool in evaluating distant metastasis or recurrence in patients with gastric LELC.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHEpstein-Barr Virus Infections-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHGastrectomy-
dc.subject.MESHHerpesvirus 4, Human-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHPreoperative Care-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHStomach Neoplasms-
dc.titleClinical usefulness of F-18 FDG PET in lymphoepithelioma-like gastric carcinoma-
dc.typeArticle-
dc.identifier.pmid28712702-
dc.contributor.affiliatedAuthor이, 다근-
dc.contributor.affiliatedAuthor이, 기명-
dc.contributor.affiliatedAuthor한, 상욱-
dc.contributor.affiliatedAuthor이, 제희-
dc.contributor.affiliatedAuthor이, 수진-
dc.contributor.affiliatedAuthor안, 영실-
dc.contributor.affiliatedAuthor윤, 준기-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ejrad.2017.06.022-
dc.citation.titleEuropean journal of radiology-
dc.citation.volume94-
dc.citation.date2017-
dc.citation.startPage160-
dc.citation.endPage166-
dc.identifier.bibliographicCitationEuropean journal of radiology, 94. : 160-166, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1872-7727-
dc.relation.journalidJ00720048X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
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