The combined effect of Adiponectin and Visceral fat on Impaired Insulin Sensitivity and Insulin Secretion

Abstract

1.Objectives: To examine the combined effects of adiponcetin levels and Visceral Adipose Tissue (VAT) mass on the risk of impaired insulin sensitivity and insulin secretion. 2.Methods: This research enrolled 1,347 participants (501 men, 846 women) aged 30 to 64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center of Korea. These participants were stratified into six groups according to combination of the adiponectin level (tertiles) and visceral fat level (< 75 %tile or ≥75 %tile). For each group, odds ratio of insulin sensitivity and insulin secretion ability (beta-cell function) were measured to evaluate their correlation with each other. 3.Results: After adjusting for age, body mass index, hs-CRP, triglyceride, and physical activity, odds ratio[95% confidence interval] for insulin sensitivity (HOMA-IR ≥ 2.5) in groups 2, 3, 4, 5, and 6 compared to the group 1 (highest tertile of adiponectin and VAT < 75%tile) were 2.06 (1.26 – 3.37), 3.31 (2.05 – 5.33), 4.08 (2.00 – 8.35), 5.88 (3.25 – 10.65), and 13.79 (7.65 – 24.83), respectively. Odds ratio (95% CI) for insulin sensitivity (Matsuda index ≤ 25%tile) in groups 2, 3, 4, 5, and 6 compared to group 1 were 1.33 (0.78 – 2.25), 2.60 (1.59 – 4.25), 4.22 (2.05 – 8.67), 4.99 (2.74 – 9.08), and 8.80 (4.91 – 15.78), respectively. Odds ratio (95% CI) for beta-cell dysfunction (HOMA-B% ≤ 25%tile) in groups 2, 3, 4, 5, and 6 compared to group 1 were 0.99 (0.68 – 1.43), 1.43 (0.98 – 2.07), 0.65 (0.29 – 1.42), 1.46 (0.85 – 2.51), and 1.36 (0.80 – 2.31), respectively. Odds ratio (95% CI) for beta-cell dysfunction (insulinogenic index ≤ 25%tile) in groups 2, 3, 4, 5, and 6 compared to group 1 were 0.62 (0.43 – 0.89), 0.86 (0.60 – 1.25), 0.91 (0.46 – 1.78), 1.18 (0.70 – 1.97), and 1.00 (0.60 – 1.64), respectively. 4.Conclusion: This study showed a combined effect of decreasing adiponectin levels and increasing VAT on insulin sensitivity.