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Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells

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dc.contributor.authorShin, H-
dc.contributor.authorHan, JH-
dc.contributor.authorYoon, J-
dc.contributor.authorSim, HJ-
dc.contributor.authorPark, TJ-
dc.contributor.authorYang, S-
dc.contributor.authorLee, EK-
dc.contributor.authorKulkarni, RN-
dc.contributor.authorEgan, JM-
dc.contributor.authorKim, W-
dc.date.accessioned2019-11-13T00:17:46Z-
dc.date.available2019-11-13T00:17:46Z-
dc.date.issued2018-
dc.identifier.issn1582-1838-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/16750-
dc.description.abstractCannabinoid 1 receptors (CB1Rs) are expressed in peripheral tissues, including islets of Langerhans, where their function(s) is under scrutiny. Using mouse beta-cell lines, human islets and CB1R-null (CB1R(-/-) ) mice, we have now investigated the role of CB1Rs in modulating beta-cell function and glucose responsiveness. Synthetic CB1R agonists diminished GLP-1-mediated cAMP accumulation and insulin secretion as well as glucose-stimulated insulin secretion in mouse beta-cell lines and human islets. In addition, silencing CB1R in mouse beta cells resulted in an increased expression of pro-insulin, glucokinase (GCK) and glucose transporter 2 (GLUT2), but this increase was lost in beta cells lacking insulin receptor. Furthermore, CB1R(-/-) mice had increased pro-insulin, GCK and GLUT2 expression in beta cells. Our results suggest that CB1R signalling in pancreatic islets may be harnessed to improve beta-cell glucose responsiveness and preserve their function. Thus, our findings further support that blocking peripheral CB1Rs would be beneficial to beta-cell function in type 2 diabetes.-
dc.language.isoen-
dc.titleBlockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells-
dc.typeArticle-
dc.identifier.pmid29431265-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867156/-
dc.subject.keywordcannabinoid 1 receptor-
dc.subject.keywordglucokinase-
dc.subject.keywordglucose transporter 2-
dc.subject.keywordinsulin secretion-
dc.subject.keywordβ-cell function-
dc.contributor.affiliatedAuthor양, 시영-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/jcmm.13523-
dc.citation.titleJournal of cellular and molecular medicine-
dc.citation.volume22-
dc.citation.number4-
dc.citation.date2018-
dc.citation.startPage2337-
dc.citation.endPage2345-
dc.identifier.bibliographicCitationJournal of cellular and molecular medicine, 22(4). : 2337-2345, 2018-
dc.identifier.eissn1582-4934-
dc.relation.journalidJ015821838-
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Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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