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Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells
DC Field | Value | Language |
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dc.contributor.author | Shin, H | - |
dc.contributor.author | Han, JH | - |
dc.contributor.author | Yoon, J | - |
dc.contributor.author | Sim, HJ | - |
dc.contributor.author | Park, TJ | - |
dc.contributor.author | Yang, S | - |
dc.contributor.author | Lee, EK | - |
dc.contributor.author | Kulkarni, RN | - |
dc.contributor.author | Egan, JM | - |
dc.contributor.author | Kim, W | - |
dc.date.accessioned | 2019-11-13T00:17:46Z | - |
dc.date.available | 2019-11-13T00:17:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1582-1838 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/16750 | - |
dc.description.abstract | Cannabinoid 1 receptors (CB1Rs) are expressed in peripheral tissues, including islets of Langerhans, where their function(s) is under scrutiny. Using mouse beta-cell lines, human islets and CB1R-null (CB1R(-/-) ) mice, we have now investigated the role of CB1Rs in modulating beta-cell function and glucose responsiveness. Synthetic CB1R agonists diminished GLP-1-mediated cAMP accumulation and insulin secretion as well as glucose-stimulated insulin secretion in mouse beta-cell lines and human islets. In addition, silencing CB1R in mouse beta cells resulted in an increased expression of pro-insulin, glucokinase (GCK) and glucose transporter 2 (GLUT2), but this increase was lost in beta cells lacking insulin receptor. Furthermore, CB1R(-/-) mice had increased pro-insulin, GCK and GLUT2 expression in beta cells. Our results suggest that CB1R signalling in pancreatic islets may be harnessed to improve beta-cell glucose responsiveness and preserve their function. Thus, our findings further support that blocking peripheral CB1Rs would be beneficial to beta-cell function in type 2 diabetes. | - |
dc.language.iso | en | - |
dc.title | Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells | - |
dc.type | Article | - |
dc.identifier.pmid | 29431265 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867156/ | - |
dc.subject.keyword | cannabinoid 1 receptor | - |
dc.subject.keyword | glucokinase | - |
dc.subject.keyword | glucose transporter 2 | - |
dc.subject.keyword | insulin secretion | - |
dc.subject.keyword | β-cell function | - |
dc.contributor.affiliatedAuthor | 양, 시영 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/jcmm.13523 | - |
dc.citation.title | Journal of cellular and molecular medicine | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.date | 2018 | - |
dc.citation.startPage | 2337 | - |
dc.citation.endPage | 2345 | - |
dc.identifier.bibliographicCitation | Journal of cellular and molecular medicine, 22(4). : 2337-2345, 2018 | - |
dc.identifier.eissn | 1582-4934 | - |
dc.relation.journalid | J015821838 | - |
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