Cited 0 times in Scipus Cited Count

Prion-like Propagation of alpha-Synuclein Is Regulated by the FcgammaRIIB-SHP-1/2 Signaling Pathway in Neurons

Authors
Choi, YR | Cha, SH | Kang, SJ | Kim, JB | Jou, I  | Park, SM
Citation
Cell reports, 22(1). : 136-148, 2018
Journal Title
Cell reports
ISSN
2211-1247
Abstract
Recent evidence of prion-like propagation of alpha-synuclein (alpha-syn) into neighboring neurons set up a paradigm to elucidate the mechanism of progression of Parkinson's disease (PD) and to develop therapeutic strategies. Here, we show that FcgammaRIIB expressed in neurons functions as a receptor for alpha-syn fibrils and mediates cell-to-cell transmission of alpha-syn. SHP-1 and 2 are activated downstream by alpha-syn fibrils through FcgammaRIIB and play an important role in cell-to-cell transmission of alpha-syn. Also, taking advantage of a co-culture system, we show that cell-to-cell transmission of alpha-syn induces intracellular Lewy body-like inclusion body formation and that the FcgammaRIIB/SHP-1/2 signaling pathway is involved in it. Therefore, the FcgammaRIIB-SHP-1/-2 signaling pathway may be a therapeutic target for the progression of PD. The in vitro system is an efficient tool for further high-throughput screening that can be used for developing a therapeutic intervention in PD.
MeSH

DOI
10.1016/j.celrep.2017.12.009
PMID
29298416
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Ajou Authors
박, 상면  |  주, 일로
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse