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Comparison of Breast Conserving Surgery Followed by Radiation Therapy with Mastectomy Alone for Pathologic N1 Breast Cancer Patients in the Era of Anthracycline Plus Taxane-Based Chemotherapy: A Multicenter Retrospective Study (KROG 1418)
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dc.contributor.author | Yoo, GS | - |
dc.contributor.author | Park, W | - |
dc.contributor.author | Yu, JI | - |
dc.contributor.author | Choi, DH | - |
dc.contributor.author | Kim, YJ | - |
dc.contributor.author | Shin, KH | - |
dc.contributor.author | Wee, CW | - |
dc.contributor.author | Kim, K | - |
dc.contributor.author | Park, KR | - |
dc.contributor.author | Kim, YB | - |
dc.contributor.author | Ahn, SJ | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Chun, M | - |
dc.contributor.author | Lee, HS | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Cha, J | - |
dc.date.accessioned | 2020-10-21T07:20:42Z | - |
dc.date.available | 2020-10-21T07:20:42Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/18787 | - |
dc.description.abstract | PURPOSE: We compared the oncologic outcomes of breast-conserving surgery plus radiation therapy (BCS+RT) and modified radical mastectomy (MRM) under anthracycline plus taxane-based (AT) regimens and investigated the role of adjuvant radiation therapy (RT) in patients with pathologic N1 (pN1) breast cancer treated by mastectomy.
MATERIALS AND METHODS: We retrospectively reviewed the medical records of 2,011 patients with pN1 breast cancer who underwent BCS+RT or MRM alone at 12 institutions between January 2006 and December 2010. Two-to-one propensity score matching was performed for balances in variables between the groups. RESULTS: The median follow-up duration for the total cohort was 69 months (range, 1 to 114 months). After propensity score matching, 1,074 patients (676 in the BCS+RT group and 398 in the MRM-alone group) were analyzed finally. The overall survival, disease-free survival, locoregional failure-free survival, and regional failure-free survival (RFFS) curves of the BCS+RT group vs. MRM-alone group were not significantly different. The subgroup analysis revealed that in the group with both lymphovascular invasion (LVI) and histologic grade (HG) III, the BCS+RT showed significantly superior RFFS (p=0.008). Lymphedema (p=0.007) and radiation pneumonitis (p=0.031) occurred more frequently in the BCS+RT group than in the MRM-alone group, significantly. CONCLUSION: There are no differences in oncologic outcomes between BCS+RT and MRM-alone groups under the AT chemotherapy regimens for pN1 breast cancer. However, BCS+RT group showed superior RFFS to MRM-alone group in the patients with LVI and HG III. Adjuvant RT might be considerable for pN1 breast cancer patients with LVI and HG III. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anthracyclines | - |
dc.subject.MESH | Breast Neoplasms | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mastectomy | - |
dc.subject.MESH | Mastectomy, Segmental | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Taxoids | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Comparison of Breast Conserving Surgery Followed by Radiation Therapy with Mastectomy Alone for Pathologic N1 Breast Cancer Patients in the Era of Anthracycline Plus Taxane-Based Chemotherapy: A Multicenter Retrospective Study (KROG 1418) | - |
dc.type | Article | - |
dc.identifier.pmid | 30384580 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639204/ | - |
dc.subject.keyword | Anthracyclines | - |
dc.subject.keyword | Breast conserving surgery | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Mastectomy | - |
dc.subject.keyword | Pathologic N1 | - |
dc.subject.keyword | Radiation Radiotherapy | - |
dc.subject.keyword | Taxane | - |
dc.contributor.affiliatedAuthor | 전, 미선 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.4143/crt.2018.424 | - |
dc.citation.title | Cancer research and treatment | - |
dc.citation.volume | 51 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2019 | - |
dc.citation.startPage | 1041 | - |
dc.citation.endPage | 1051 | - |
dc.identifier.bibliographicCitation | Cancer research and treatment, 51(3). : 1041-1051, 2019 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.relation.journalid | J015982998 | - |
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