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Comparison of Breast Conserving Surgery Followed by Radiation Therapy with Mastectomy Alone for Pathologic N1 Breast Cancer Patients in the Era of Anthracycline Plus Taxane-Based Chemotherapy: A Multicenter Retrospective Study (KROG 1418)

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dc.contributor.authorYoo, GS-
dc.contributor.authorPark, W-
dc.contributor.authorYu, JI-
dc.contributor.authorChoi, DH-
dc.contributor.authorKim, YJ-
dc.contributor.authorShin, KH-
dc.contributor.authorWee, CW-
dc.contributor.authorKim, K-
dc.contributor.authorPark, KR-
dc.contributor.authorKim, YB-
dc.contributor.authorAhn, SJ-
dc.contributor.authorLee, JH-
dc.contributor.authorKim, JH-
dc.contributor.authorChun, M-
dc.contributor.authorLee, HS-
dc.contributor.authorKim, JS-
dc.contributor.authorCha, J-
dc.date.accessioned2020-10-21T07:20:42Z-
dc.date.available2020-10-21T07:20:42Z-
dc.date.issued2019-
dc.identifier.issn1598-2998-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18787-
dc.description.abstractPURPOSE: We compared the oncologic outcomes of breast-conserving surgery plus radiation therapy (BCS+RT) and modified radical mastectomy (MRM) under anthracycline plus taxane-based (AT) regimens and investigated the role of adjuvant radiation therapy (RT) in patients with pathologic N1 (pN1) breast cancer treated by mastectomy.
MATERIALS AND METHODS: We retrospectively reviewed the medical records of 2,011 patients with pN1 breast cancer who underwent BCS+RT or MRM alone at 12 institutions between January 2006 and December 2010. Two-to-one propensity score matching was performed for balances in variables between the groups.
RESULTS: The median follow-up duration for the total cohort was 69 months (range, 1 to 114 months). After propensity score matching, 1,074 patients (676 in the BCS+RT group and 398 in the MRM-alone group) were analyzed finally. The overall survival, disease-free survival, locoregional failure-free survival, and regional failure-free survival (RFFS) curves of the BCS+RT group vs. MRM-alone group were not significantly different. The subgroup analysis revealed that in the group with both lymphovascular invasion (LVI) and histologic grade (HG) III, the BCS+RT showed significantly superior RFFS (p=0.008). Lymphedema (p=0.007) and radiation pneumonitis (p=0.031) occurred more frequently in the BCS+RT group than in the MRM-alone group, significantly.
CONCLUSION: There are no differences in oncologic outcomes between BCS+RT and MRM-alone groups under the AT chemotherapy regimens for pN1 breast cancer. However, BCS+RT group showed superior RFFS to MRM-alone group in the patients with LVI and HG III. Adjuvant RT might be considerable for pN1 breast cancer patients with LVI and HG III.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAnthracyclines-
dc.subject.MESHBreast Neoplasms-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMastectomy-
dc.subject.MESHMastectomy, Segmental-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPropensity Score-
dc.subject.MESHRadiotherapy, Adjuvant-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTaxoids-
dc.subject.MESHTreatment Outcome-
dc.titleComparison of Breast Conserving Surgery Followed by Radiation Therapy with Mastectomy Alone for Pathologic N1 Breast Cancer Patients in the Era of Anthracycline Plus Taxane-Based Chemotherapy: A Multicenter Retrospective Study (KROG 1418)-
dc.typeArticle-
dc.identifier.pmid30384580-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639204/-
dc.subject.keywordAnthracyclines-
dc.subject.keywordBreast conserving surgery-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordMastectomy-
dc.subject.keywordPathologic N1-
dc.subject.keywordRadiation Radiotherapy-
dc.subject.keywordTaxane-
dc.contributor.affiliatedAuthor전, 미선-
dc.type.localJournal Papers-
dc.identifier.doi10.4143/crt.2018.424-
dc.citation.titleCancer research and treatment-
dc.citation.volume51-
dc.citation.number3-
dc.citation.date2019-
dc.citation.startPage1041-
dc.citation.endPage1051-
dc.identifier.bibliographicCitationCancer research and treatment, 51(3). : 1041-1051, 2019-
dc.identifier.eissn2005-9256-
dc.relation.journalidJ015982998-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
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