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Interaction between coxsackievirus B3 infection and α-synuclein in Parkinson’s disease
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 박, 상면 | - |
| dc.contributor.author | 박, 수진 | - |
| dc.date.accessioned | 2021-11-10T05:51:57Z | - |
| dc.date.available | 2021-11-10T05:51:57Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/19776 | - |
| dc.description.abstract | 비공개 | - |
| dc.description.tableofcontents | Ⅰ. INTRODUCTION 1
A. Parkinson's disease 1 B. Prion-like propagation of α-syn in PD 1 C. Virus infection as a risk factor for PD 2 D. Coxsackievirus B3 3 E. Virus infection and protein aggregation in neurodegenerative disease 3 F. Aims 4 Ⅱ. MATERIALS AND METHODS 5 A. Antibodies and Reagents 5 B. Animals 5 C. Cell culture 6 D. Infection of coxsackievirus B3 (CVB3) 7 E. Tissue preparation 7 F. Immunocytochemistry (ICC) 8 G. Western blot 8 H. Reverse transcription polymerase chain reaction (RT-PCR) 9 I. Transmission electron microscopy (TEM) 10 J. Mitochondrial analysis 10 K. Cytotoxicity assay 11 L. Flow cytometry 11 M. Immunohistochemistry (IHC) 12 N. Evans Blue Dye Staining of CVB3 infected mice hearts 12 O. Cell density analysis 12 P. Transcriptome data and gene expression analysis 13 Q. Network analysis 14 R. Statistical analysis 14 Ⅲ. RESULTS 15 A. Effects of CVB3 on α-syn 15 1. CVB3 infection regulates α-syn expression in neurons 15 2. CVB3 infection induces Lewy body-like inclusion body formation in neurons 22 B. Effects of α-syn on CVB3 29 1. α-Syn regulates the maturation of LB-like inclusion body induced by CVB3 29 2. α-Syn regulates the replication of CVB3 in neurons 34 C. Mechanism of interaction between CVB3 and α-Syn 38 1. CVB3 and α-syn differentially regulate autophagic activity 38 D. Interaction between CVB3 and α-Syn in in vivo 44 1. α-Syn regulates the replication of CVB3 in the mouse brain 44 2. CVB3 induces the formation of α-syn inclusions in the mouse brain 56 Ⅳ. DISCUSSION 59 Ⅴ. CONCLUSIONS 71 REFERENCES 73 국문요약 87 | - |
| dc.language.iso | en | - |
| dc.title | Interaction between coxsackievirus B3 infection and α-synuclein in Parkinson’s disease | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000030510 | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | 대학원 의생명과학과 | - |
| dc.contributor.affiliatedAuthor | 박, 수진 | - |
| dc.date.awarded | 2021 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2021 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
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