Cited 0 times in Scipus Cited Count

Diastolic dysfunction is associated with an increased risk of postcontrast acute kidney injury

Authors
Lee, MJ  | Park, JS  | Kim, HH
Citation
Medicine, 98(48). : e17994-e17994, 2019
Journal Title
Medicine
ISSN
0025-79741536-5964
Abstract
STUDY OBJECTIVE: Computed tomography (CT) is an important imaging modality in diagnosing a variety of disorders. Although systolic heart failure is a well-known risk factor for postcontrast acute kidney injury (PC-AKI), few studies have evaluated the association between diastolic dysfunction and PC-AKI. Therefore, the aim of our study was to investigate whether PC-AKI occurs more likely in patients with diastolic dysfuction.
METHODS: This retrospective study was conducted by collecting the data of patients who visited an emergency medical center between January 2008 and December 2014. Patients who underwent contrast-enhanced CT (CECT) in the emergency department and had undergone echocardiography within 1 month of CECT were included. We defined PC-AKI as an elevation in the serum creatinine level of >/=0.5 mg/dL or >/=25% within 72 hours after CECT.
RESULTS: We included 327 patients, aged 18 years and older, who had a CECT scan and underwent an echocardiography within 1 month of the CECT scan at our institute over 20 years. The mean value of estimated glomerular filtration rate and E/E (early left ventricular filling velocity to early diastolic mitral annular velocity ratio) was 51.55 +/- 7.66 mL.min.1.73 m and 11.56 +/- 5.33, respectively. A total of 32 patients (9.79%) developed PC-AKI. The prevalence of diabetes mellitus and chronic kidney disease was significantly higher in the PC-AKI group than in the non-PC-AKI group. Echocardiographic findings revealed that E/E was significantly increased in patients with PC-AKI. The logistic regression analysis showed that a higher E/E value (odds ratio [OR] 5.39, 95% confidence interval [CI] 1.51-25.23, P = .015) was a significant risk factor for PC-AKI.
CONCLUSION: This study demonstrated that, among the echocardiographic variables, E/E was an independent predictor of PC- AKI. This, in turn, suggests that diastolic dysfunction may be a useful parameter in PC-AKI risk stratification.
Keywords

MeSH

DOI
10.1097/MD.0000000000017994
PMID
31770210
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Nephrology
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Journal Papers > School of Medicine / Graduate School of Medicine > Emergency Medicine
Ajou Authors
김, 혁훈  |  박, 진선  |  이, 민정
Full Text Link
Files in This Item:
31770210.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse