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Metabolic shift favoring C18:0 ceramide accumulation in obese asthma

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dc.contributor.authorChoi, Y-
dc.contributor.authorKim, M-
dc.contributor.authorKim, SJ-
dc.contributor.authorYoo, HJ-
dc.contributor.authorKim, SH-
dc.contributor.authorPark, HS-
dc.date.accessioned2022-10-28T05:28:54Z-
dc.date.available2022-10-28T05:28:54Z-
dc.date.issued2020-
dc.identifier.issn0105-4538-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22463-
dc.description.abstractBACKGROUND: Obesity associated with various complications has increased worldwide. Body weight gain alters lipid metabolites (especially sphingolipids) contributing to obesity-induced inflammation. However, the significance of the metabolites in the development of obese asthma is not yet clear.

METHODS: The serum levels of sphingolipids were measured using liquid chromatography-tandem mass spectrometry in obese controls (n = 7) and patients with asthma: the obese group (BMI > 25 kg/m(2) , n = 13) vs the nonobese (n = 28) group. To examine the relationship between metabolic changes in sphingolipids and macrophage polarization, public microarray data were analyzed. In addition, the alteration in sphingolipid metabolism was investigated in wild-type BALB/c mice fed a high-fat diet.

RESULTS: The obese asthma had higher levels of serum C18:0 and C20:0 ceramides than the nonobese asthma group (P = .028 and P = .040, respectively). The value of the serum C18:0 ceramide (184.3 ng/mL) for discriminating the obese asthma from the nonobese asthma group showed 53.9% sensitivity and 85.7% specificity (AUC = 0.721, P = .024). The microarray data showed significantly increased ceramide synthesis and metabolic shift to ceramide accumulation during M1 macrophage polarization in humans. Increased airway hyperresponsiveness, M1 macrophage polarization, and C18:0 ceramide levels were noted in obese mice, but not in nonobese mice. Increased expression of ceramide synthase (CerS) 1 and CerS6 (not CerS2) was noted in lung tissues of obese mice.

CONCLUSION: Alteration in sphingolipid metabolism favoring ceramide accumulation (especially long-chain ceramides) may contribute to developing obese asthma.
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dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHAsthma-
dc.subject.MESHCeramides-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHObesity-
dc.subject.MESHSphingolipids-
dc.titleMetabolic shift favoring C18:0 ceramide accumulation in obese asthma-
dc.typeArticle-
dc.identifier.pmid32416622-
dc.subject.keywordasthma-
dc.subject.keywordceramide-
dc.subject.keywordmacrophage-
dc.subject.keywordobesity-
dc.subject.keywordsphingolipid-
dc.contributor.affiliatedAuthorChoi, Y-
dc.contributor.affiliatedAuthorKim, SH-
dc.contributor.affiliatedAuthorPark, HS-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/all.14366-
dc.citation.titleAllergy-
dc.citation.volume75-
dc.citation.number11-
dc.citation.date2020-
dc.citation.startPage2858-
dc.citation.endPage2866-
dc.identifier.bibliographicCitationAllergy, 75(11). : 2858-2866, 2020-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1398-9995-
dc.relation.journalidJ001054538-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Hospital > Clinical Trial Center
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