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Metabolic shift favoring C18:0 ceramide accumulation in obese asthma
DC Field | Value | Language |
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dc.contributor.author | Choi, Y | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Yoo, HJ | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2022-10-28T05:28:54Z | - |
dc.date.available | 2022-10-28T05:28:54Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0105-4538 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/22463 | - |
dc.description.abstract | BACKGROUND: Obesity associated with various complications has increased worldwide. Body weight gain alters lipid metabolites (especially sphingolipids) contributing to obesity-induced inflammation. However, the significance of the metabolites in the development of obese asthma is not yet clear.
METHODS: The serum levels of sphingolipids were measured using liquid chromatography-tandem mass spectrometry in obese controls (n = 7) and patients with asthma: the obese group (BMI > 25 kg/m(2) , n = 13) vs the nonobese (n = 28) group. To examine the relationship between metabolic changes in sphingolipids and macrophage polarization, public microarray data were analyzed. In addition, the alteration in sphingolipid metabolism was investigated in wild-type BALB/c mice fed a high-fat diet. RESULTS: The obese asthma had higher levels of serum C18:0 and C20:0 ceramides than the nonobese asthma group (P = .028 and P = .040, respectively). The value of the serum C18:0 ceramide (184.3 ng/mL) for discriminating the obese asthma from the nonobese asthma group showed 53.9% sensitivity and 85.7% specificity (AUC = 0.721, P = .024). The microarray data showed significantly increased ceramide synthesis and metabolic shift to ceramide accumulation during M1 macrophage polarization in humans. Increased airway hyperresponsiveness, M1 macrophage polarization, and C18:0 ceramide levels were noted in obese mice, but not in nonobese mice. Increased expression of ceramide synthase (CerS) 1 and CerS6 (not CerS2) was noted in lung tissues of obese mice. CONCLUSION: Alteration in sphingolipid metabolism favoring ceramide accumulation (especially long-chain ceramides) may contribute to developing obese asthma. | - |
dc.language.iso | en | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | Ceramides | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Obesity | - |
dc.subject.MESH | Sphingolipids | - |
dc.title | Metabolic shift favoring C18:0 ceramide accumulation in obese asthma | - |
dc.type | Article | - |
dc.identifier.pmid | 32416622 | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | ceramide | - |
dc.subject.keyword | macrophage | - |
dc.subject.keyword | obesity | - |
dc.subject.keyword | sphingolipid | - |
dc.contributor.affiliatedAuthor | Choi, Y | - |
dc.contributor.affiliatedAuthor | Kim, SH | - |
dc.contributor.affiliatedAuthor | Park, HS | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/all.14366 | - |
dc.citation.title | Allergy | - |
dc.citation.volume | 75 | - |
dc.citation.number | 11 | - |
dc.citation.date | 2020 | - |
dc.citation.startPage | 2858 | - |
dc.citation.endPage | 2866 | - |
dc.identifier.bibliographicCitation | Allergy, 75(11). : 2858-2866, 2020 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.identifier.eissn | 1398-9995 | - |
dc.relation.journalid | J001054538 | - |
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