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Hepatitis B Prophylaxis after Liver Transplantation in Korea: Analysis of the KOTRY Database

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dc.contributor.authorPark, GC-
dc.contributor.authorHwang, S-
dc.contributor.authorKim, MS-
dc.contributor.authorJung, DH-
dc.contributor.authorSong, GW-
dc.contributor.authorLee, KW-
dc.contributor.authorKim, JM-
dc.contributor.authorLee, JG-
dc.contributor.authorRyu, JH-
dc.contributor.authorChoi, DL-
dc.contributor.authorWang, HJ-
dc.contributor.authorKim, BW-
dc.contributor.authorKim, DS-
dc.contributor.authorNah, YW-
dc.contributor.authorYou, YK-
dc.contributor.authorKang, KJ-
dc.contributor.authorYu, HC-
dc.contributor.authorPark, YH-
dc.contributor.authorLee, KJ-
dc.contributor.authorKim, YK-
dc.date.accessioned2022-11-11T04:09:36Z-
dc.date.available2022-11-11T04:09:36Z-
dc.date.issued2020-
dc.identifier.issn1011-8934-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22558-
dc.description.abstractBACKGROUND: Prophylaxis for hepatitis B virus (HBV) recurrence is essential after liver transplantation (LT) in HBV-associated recipients. We conducted real-world analysis of HBV prophylaxis after LT in the Korean population. METHODS: Korean Organ Transplantation Registry (KOTRY) database and additionally collected data (n = 326) were analyzed with special reference to types of HBV prophylaxis. RESULTS: The study cohort comprised 267 cases of living-donor LT and 59 cases of deceased-donor LT. Hepatocellular carcinoma (HCC) was diagnosed in 232 (71.2%) of these subjects. Antiviral agents were used in 255 patients (78.2%) prior to LT. HBV DNA was undetectable in 69 cases (21.2%) and detectable over wide concentrations in the other 257 patients (78.8%) prior to LT. Polymerase chain reaction analysis of the store blood samples detected HBV DNA in all patients, with 159 patients (48.9%) showing concentrations > 100 IU/mL. Post-transplant HBV regimens during the first year included combination therapy in 196 (60.1%), hepatitis B immunoglobulin (HBIG) monotherapy in 121 (37.1%), and antiviral monotherapy in 9 (2.8%). In the second post-transplant year, these regimens had changed to combination therapy in 187 (57.4%), HBIG monotherapy in 112 (34.4%), and antiviral monotherapy in 27 (8.3%). Trough antibody to hepatitis B surface antigen titers > 500 IU/mL and >1,000 IU/mL were observed in 61.7% and 25.2%, respectively. The mean simulative half-life of HBIG was 21.6 +/- 4.3 days with a median 17.7 days. Up to 2-year follow-up period, HCC recurrence and HBV recurrence developed in 18 (5.5%) and 6 (1.8%), respectively. HCC recurrence developed in 3 of 6 patients with HBV recurrence. CONCLUSION: Combination therapy is the mainstay of HBV prophylaxis protocols in a majority of Korean LT centers, but HBIG was often administered excessively. Individualized optimization of HBIG treatments using SHL is necessary to adjust the HBIG infusion interval.-
dc.language.isoen-
dc.subject.MESHAntiviral Agents-
dc.subject.MESHCohort Studies-
dc.subject.MESHDNA, Viral-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHHepatitis B Surface Antigens-
dc.subject.MESHHepatitis B virus-
dc.subject.MESHHepatitis B-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulins-
dc.subject.MESHLiver Transplantation-
dc.subject.MESHLiving Donors-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.titleHepatitis B Prophylaxis after Liver Transplantation in Korea: Analysis of the KOTRY Database-
dc.typeArticle-
dc.identifier.pmid32056398-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025905-
dc.subject.keywordHepatitis B Virus-
dc.subject.keywordRecurrence-
dc.subject.keywordLiver Transplantation-
dc.subject.keywordHepatitis B Immunoglobulin-
dc.subject.keywordAntiviral Agent-
dc.contributor.affiliatedAuthorKim, BW-
dc.type.localJournal Papers-
dc.identifier.doi10.3346/jkms.2020.35.e36-
dc.citation.titleJournal of Korean medical science-
dc.citation.volume35-
dc.citation.number6-
dc.citation.date2020-
dc.citation.startPagee36-
dc.citation.endPagee36-
dc.identifier.bibliographicCitationJournal of Korean medical science, 35(6). : e36-e36, 2020-
dc.identifier.eissn1598-6357-
dc.relation.journalidJ010118934-
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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