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Discordant genetic changes in ovarian and endometrial endometrioid carcinomas: a potential pitfall in molecular diagnosis.

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dc.contributor.authorChang, KH-
dc.contributor.authorAlbarracin, C-
dc.contributor.authorLuthra, R-
dc.contributor.authorWang, L-
dc.contributor.authorZheng, W-
dc.contributor.authorMalpica, A-
dc.contributor.authorDeavers, MT-
dc.contributor.authorSilva, EG-
dc.contributor.authorLiu, J-
dc.date.accessioned2011-04-13T05:23:39Z-
dc.date.available2011-04-13T05:23:39Z-
dc.date.issued2006-
dc.identifier.issn1048-891X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2262-
dc.description.abstractEndometrioid carcinoma simultaneously involving ovaries as well as the uterine corpus may present a diagnostic dilemma because of the difficulty in determining whether the lesions are separate primary tumors or metastases. It has been reported that the detection of clonality using microsatellite markers may be useful in solving this dilemma. To determine the usefulness of this technique, we compared the genetic alterations in microsatellite markers present in matched pairs of ovarian tumors from 12 patients. The study includes four ovarian cancer FIGO stage I and eight stage III/IV patients, and four patients also with independent endometrial carcinoma of the uterus. DNA from paraffin-embedded tissue was extracted and amplified using a multiplex polymerase chain reaction, after which the status of microsatellite instability and loss of heterozygosity in four microsatellite loci (BAT25, BAT26, D17S250, and D5S346) were determined. In the four patients with stage I ovarian cancer, four microsatellite markers were identical in one patient and three were identical in the remaining three patients. In high-stage patients, three markers were identical in at least 4/8 cases. In three of four patients with uterine involvement, three of the four markers were identical in the uterine tumor and one of the corresponding ovarian tumors. These results suggest that genetic discordance does not indicate independent origin or metastasis of the tumor but instead a progression of genetic changes at separate sites probably due to the marked genetic instability existing in these tumors. Because of these discordant genetic changes, great caution should be taken when distinguishing between primary and metastatic tumors on the basis of microsatellite markers.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiopsy, Needle-
dc.subject.MESHDNA Sequence, Unstable-
dc.subject.MESHDNA, Neoplasm-
dc.subject.MESHEndometrial Neoplasms-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMicrosatellite Repeats-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Biology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeoplasms, Multiple Primary-
dc.subject.MESHOvarian Neoplasms-
dc.subject.MESHSampling Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTissue Culture Techniques-
dc.subject.MESHbeta Catenin-
dc.titleDiscordant genetic changes in ovarian and endometrial endometrioid carcinomas: a potential pitfall in molecular diagnosis.-
dc.typeArticle-
dc.identifier.pmid16445630-
dc.contributor.affiliatedAuthor장, 기홍-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1525-1438.2006.00293.x-
dc.citation.titleInternational journal of gynecological cancer-
dc.citation.volume16-
dc.citation.number1-
dc.citation.date2006-
dc.citation.startPage178-
dc.citation.endPage182-
dc.identifier.bibliographicCitationInternational journal of gynecological cancer, 16(1). : 178-182, 2006-
dc.identifier.eissn1525-1438-
dc.relation.journalidJ01048891X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
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