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Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial
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dc.contributor.author | Woo, SD | - |
dc.contributor.author | Ye, YM | - |
dc.contributor.author | Lee, Y | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Shin, YS | - |
dc.contributor.author | Park, JH | - |
dc.contributor.author | Choi, H | - |
dc.contributor.author | Lee, HY | - |
dc.contributor.author | Shin, HJ | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2022-12-07T05:53:43Z | - |
dc.date.available | 2022-12-07T05:53:43Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/23241 | - |
dc.description.abstract | PURPOSE: Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone propionate/formoterol treatment using a pressurized metered-dose inhaler [p-MDI group] vs. fluticasone propionate/salmeterol treatment using a dry powder inhaler [DPI group]) in older asthmatics. METHODS: We conducted a 12-week, randomized, open-label, parallel-designed trial in older patients (over 55 years old) with moderate-to-severe asthma, and compared the efficacy and safety for asthma control between the 2 groups. Subgroup analyses on disease duration and air trapping were performed. Clinical parameters, including changes in lung function parameters, inhaler technique and adherence, were compared with monitoring adverse reactions between the 2 groups. RESULTS: A total of 68 patients underwent randomization, and 63 (30 in the p-MDI group and 33 in the DPI group) completed this study. The p-MDI group was non-inferior to the DPI group with regard to the rate of well-controlled asthma (53.3% vs. 45.5%, p < 0.001; a predefined non-inferiority limit of 17%). In subgroup analyses, the proportion of patients who did not reach well-controlled asthma in the p-MDI group was non-inferior to that in the DPI group; the difference was 12.7% among those with a longer disease duration (>/= 15 years) and 17.5% among those with higher air-trapping (RV/TLC >/= 45%), respectively (a predefined non-inferiority limit of 17%, p < 0.001). No significant differences were observed in lung function parameters, inhalation techniques, adherence and adverse reactions between the 2 groups. CONCLUSION: These results suggest that the p-MDI group may be comparable to the DPI group in the management of older asthmatics in aspects of efficacy and safety. | - |
dc.language.iso | en | - |
dc.title | Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial | - |
dc.type | Article | - |
dc.identifier.pmid | 32141259 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061154 | - |
dc.subject.keyword | Asthma | - |
dc.subject.keyword | aged | - |
dc.subject.keyword | metered dose inhalers | - |
dc.subject.keyword | dry powder inhalers | - |
dc.subject.keyword | airway management | - |
dc.subject.keyword | medication adherence | - |
dc.contributor.affiliatedAuthor | Woo, SD | - |
dc.contributor.affiliatedAuthor | Ye, YM | - |
dc.contributor.affiliatedAuthor | Lee, Y | - |
dc.contributor.affiliatedAuthor | Shin, YS | - |
dc.contributor.affiliatedAuthor | Park, JH | - |
dc.contributor.affiliatedAuthor | Park, HS | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.4168/aair.2020.12.3.454 | - |
dc.citation.title | Allergy, asthma & immunology research | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2020 | - |
dc.citation.startPage | 454 | - |
dc.citation.endPage | 466 | - |
dc.identifier.bibliographicCitation | Allergy, asthma & immunology research, 12(3). : 454-466, 2020 | - |
dc.identifier.eissn | 2092-7363 | - |
dc.relation.journalid | J020927355 | - |
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