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Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial

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dc.contributor.authorWoo, SD-
dc.contributor.authorYe, YM-
dc.contributor.authorLee, Y-
dc.contributor.authorLee, SH-
dc.contributor.authorShin, YS-
dc.contributor.authorPark, JH-
dc.contributor.authorChoi, H-
dc.contributor.authorLee, HY-
dc.contributor.authorShin, HJ-
dc.contributor.authorPark, HS-
dc.date.accessioned2022-12-07T05:53:43Z-
dc.date.available2022-12-07T05:53:43Z-
dc.date.issued2020-
dc.identifier.issn2092-7355-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23241-
dc.description.abstractPURPOSE: Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone propionate/formoterol treatment using a pressurized metered-dose inhaler [p-MDI group] vs. fluticasone propionate/salmeterol treatment using a dry powder inhaler [DPI group]) in older asthmatics. METHODS: We conducted a 12-week, randomized, open-label, parallel-designed trial in older patients (over 55 years old) with moderate-to-severe asthma, and compared the efficacy and safety for asthma control between the 2 groups. Subgroup analyses on disease duration and air trapping were performed. Clinical parameters, including changes in lung function parameters, inhaler technique and adherence, were compared with monitoring adverse reactions between the 2 groups. RESULTS: A total of 68 patients underwent randomization, and 63 (30 in the p-MDI group and 33 in the DPI group) completed this study. The p-MDI group was non-inferior to the DPI group with regard to the rate of well-controlled asthma (53.3% vs. 45.5%, p < 0.001; a predefined non-inferiority limit of 17%). In subgroup analyses, the proportion of patients who did not reach well-controlled asthma in the p-MDI group was non-inferior to that in the DPI group; the difference was 12.7% among those with a longer disease duration (>/= 15 years) and 17.5% among those with higher air-trapping (RV/TLC >/= 45%), respectively (a predefined non-inferiority limit of 17%, p < 0.001). No significant differences were observed in lung function parameters, inhalation techniques, adherence and adverse reactions between the 2 groups. CONCLUSION: These results suggest that the p-MDI group may be comparable to the DPI group in the management of older asthmatics in aspects of efficacy and safety.-
dc.language.isoen-
dc.titleEfficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial-
dc.typeArticle-
dc.identifier.pmid32141259-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061154-
dc.subject.keywordAsthma-
dc.subject.keywordaged-
dc.subject.keywordmetered dose inhalers-
dc.subject.keyworddry powder inhalers-
dc.subject.keywordairway management-
dc.subject.keywordmedication adherence-
dc.contributor.affiliatedAuthorWoo, SD-
dc.contributor.affiliatedAuthorYe, YM-
dc.contributor.affiliatedAuthorLee, Y-
dc.contributor.affiliatedAuthorShin, YS-
dc.contributor.affiliatedAuthorPark, JH-
dc.contributor.affiliatedAuthorPark, HS-
dc.type.localJournal Papers-
dc.identifier.doi10.4168/aair.2020.12.3.454-
dc.citation.titleAllergy, asthma & immunology research-
dc.citation.volume12-
dc.citation.number3-
dc.citation.date2020-
dc.citation.startPage454-
dc.citation.endPage466-
dc.identifier.bibliographicCitationAllergy, asthma & immunology research, 12(3). : 454-466, 2020-
dc.identifier.eissn2092-7363-
dc.relation.journalidJ020927355-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
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