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Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study
DC Field | Value | Language |
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dc.contributor.author | Byun, JI | - |
dc.contributor.author | Cha, KS | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Lee, WJ | - |
dc.contributor.author | Lee, HS | - |
dc.contributor.author | Sunwoo, JS | - |
dc.contributor.author | Shin, JW | - |
dc.contributor.author | Kim, TJ | - |
dc.contributor.author | Moon, J | - |
dc.contributor.author | Lee, ST | - |
dc.contributor.author | Jung, KH | - |
dc.contributor.author | Chu, K | - |
dc.contributor.author | Kim, MH | - |
dc.contributor.author | Kim, HJ | - |
dc.contributor.author | Shin, WC | - |
dc.contributor.author | Lee, SK | - |
dc.contributor.author | Jung, KY | - |
dc.date.accessioned | 2023-01-05T03:03:24Z | - |
dc.date.available | 2023-01-05T03:03:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1389-9457 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/23682 | - |
dc.description.abstract | Objective: Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA). Methods: This was a cross-sectional study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used MVPA implemented in the connectome-MVPA CONN toolbox to identify data-driven seed regions for post hoc seed-to-voxel connectivity analysis. The association between FC changes and clinical characteristics, including cognition, depression, autonomic function, and daytime sleepiness, was evaluated. Results: MVPA revealed one significant cluster located in the left posterior insular cortex. Seed-to-voxel FC analysis using the cluster as a seed showed significantly reduced FC with two clusters located in the precuneus in iRBD patients compared to the controls. The degree of FC was associated with the Montreal Cognitive Assessment-Korean version scores (r = 0.317, p = 0.025). Conclusion: This study emphasizes the insula as an important neural correlate associated with iRBD that was associated with cognitive function. | - |
dc.language.iso | en | - |
dc.subject.MESH | Brain | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Polysomnography | - |
dc.subject.MESH | REM Sleep Behavior Disorder | - |
dc.title | Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study | - |
dc.type | Article | - |
dc.identifier.pmid | 33485260 | - |
dc.subject.keyword | Cognitive function | - |
dc.subject.keyword | Functional brain imaging | - |
dc.subject.keyword | Multivariate pattern analysis (MVPA) | - |
dc.subject.keyword | Neuroimaging | - |
dc.subject.keyword | REM sleep Behavior disorder | - |
dc.contributor.affiliatedAuthor | Kim, TJ | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.sleep.2020.12.038 | - |
dc.citation.title | Sleep medicine | - |
dc.citation.volume | 79 | - |
dc.citation.date | 2021 | - |
dc.citation.startPage | 88 | - |
dc.citation.endPage | 93 | - |
dc.identifier.bibliographicCitation | Sleep medicine, 79. : 88-93, 2021 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.identifier.eissn | 1878-5506 | - |
dc.relation.journalid | J013899457 | - |
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