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Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study

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dc.contributor.authorByun, JI-
dc.contributor.authorCha, KS-
dc.contributor.authorKim, M-
dc.contributor.authorLee, WJ-
dc.contributor.authorLee, HS-
dc.contributor.authorSunwoo, JS-
dc.contributor.authorShin, JW-
dc.contributor.authorKim, TJ-
dc.contributor.authorMoon, J-
dc.contributor.authorLee, ST-
dc.contributor.authorJung, KH-
dc.contributor.authorChu, K-
dc.contributor.authorKim, MH-
dc.contributor.authorKim, HJ-
dc.contributor.authorShin, WC-
dc.contributor.authorLee, SK-
dc.contributor.authorJung, KY-
dc.date.accessioned2023-01-05T03:03:24Z-
dc.date.available2023-01-05T03:03:24Z-
dc.date.issued2021-
dc.identifier.issn1389-9457-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23682-
dc.description.abstractObjective: Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA). Methods: This was a cross-sectional study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used MVPA implemented in the connectome-MVPA CONN toolbox to identify data-driven seed regions for post hoc seed-to-voxel connectivity analysis. The association between FC changes and clinical characteristics, including cognition, depression, autonomic function, and daytime sleepiness, was evaluated. Results: MVPA revealed one significant cluster located in the left posterior insular cortex. Seed-to-voxel FC analysis using the cluster as a seed showed significantly reduced FC with two clusters located in the precuneus in iRBD patients compared to the controls. The degree of FC was associated with the Montreal Cognitive Assessment-Korean version scores (r = 0.317, p = 0.025). Conclusion: This study emphasizes the insula as an important neural correlate associated with iRBD that was associated with cognitive function.-
dc.language.isoen-
dc.subject.MESHBrain-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHPolysomnography-
dc.subject.MESHREM Sleep Behavior Disorder-
dc.titleAltered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study-
dc.typeArticle-
dc.identifier.pmid33485260-
dc.subject.keywordCognitive function-
dc.subject.keywordFunctional brain imaging-
dc.subject.keywordMultivariate pattern analysis (MVPA)-
dc.subject.keywordNeuroimaging-
dc.subject.keywordREM sleep Behavior disorder-
dc.contributor.affiliatedAuthorKim, TJ-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.sleep.2020.12.038-
dc.citation.titleSleep medicine-
dc.citation.volume79-
dc.citation.date2021-
dc.citation.startPage88-
dc.citation.endPage93-
dc.identifier.bibliographicCitationSleep medicine, 79. : 88-93, 2021-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1878-5506-
dc.relation.journalidJ013899457-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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