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Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B.
DC Field | Value | Language |
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dc.contributor.author | Kim, SU | - |
dc.contributor.author | Seo, YS | - |
dc.contributor.author | Cheong, JY | - |
dc.contributor.author | Kim, MY | - |
dc.contributor.author | Kim, JK | - |
dc.contributor.author | Um, SH | - |
dc.contributor.author | Cho, SW | - |
dc.contributor.author | Paik, SK | - |
dc.contributor.author | Lee, KS | - |
dc.contributor.author | Han, KH | - |
dc.contributor.author | Ahn, SH | - |
dc.date.accessioned | 2011-05-12T06:20:01Z | - |
dc.date.available | 2011-05-12T06:20:01Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/2573 | - |
dc.description.abstract | BACKGROUND: Interquartile range/median value (IQR/M) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan.
AIM: To investigate factors that affect the accuracy of LSM in chronic hepatitis B (CHB). METHODS: One hundred and ninety-nine patients were enrolled. Only procedures yielding > or =10 valid measurements were considered reliable. Liver fibrosis was evaluated using the Batts and Ludwig system. Liver biopsy (LB) specimens <15 mm were considered ineligible. RESULTS: The mean age (142 men and 57 women) was 40.1 years. A significant discordance (discordance of at least two stages between LB and LSM) was identified in 38 (19.1%) and 47 (23.6%) patients respectively, according to Marcellin et al. and Chan et al.'s cutoff values. In multivariate analyses, BMI and fibrosis stage (F0-2 vs. F3-4) were identified as independent predictors for significant discordance (P = 0.040; hazard ratio [HR], 1.126; 95% confidence interval [CI], 1.005-1.261 and P = 0.036; HR, 0.450; 95% CI, 0.213-0.949 respectively) with Marcellin et al.'s cutoffs, whereas fibrosis stage was the only independent predictor (P = 0.004; HR, 0.300; 95% CI, 0.131-0.685) with Chan's cutoffs. CONCLUSIONS: Success rate and IQR/M were not predictive factors of the accuracy for diagnosing liver fibrosis by Fibroscan in CHB. Fibrosis stage (F0-2) was the only factor to predict significant discordance between LB and LSM. | - |
dc.format | application/pdf | - |
dc.language.iso | en | - |
dc.title | Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B. | - |
dc.type | Article | - |
dc.identifier.pmid | 20491742 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2010&volume=32&issue=3&spage=498 | - |
dc.contributor.affiliatedAuthor | 정, 재연 | - |
dc.contributor.affiliatedAuthor | 조, 성원 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/j.1365-2036.2010.04353.x | - |
dc.citation.title | Alimentary pharmacology & therapeutics | - |
dc.citation.volume | 32 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2010 | - |
dc.citation.startPage | 498 | - |
dc.citation.endPage | 505 | - |
dc.identifier.bibliographicCitation | Alimentary pharmacology & therapeutics, 32(3). : 498-505, 2010 | - |
dc.identifier.eissn | 1365-2036 | - |
dc.relation.journalid | J002692813 | - |
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