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The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization.
DC Field | Value | Language |
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dc.contributor.author | Kubo, T | - |
dc.contributor.author | Maehara, A | - |
dc.contributor.author | Mintz, GS | - |
dc.contributor.author | Doi, H | - |
dc.contributor.author | Tsujita, K | - |
dc.contributor.author | Choi, SY | - |
dc.contributor.author | Katoh, O | - |
dc.contributor.author | Nasu, K | - |
dc.contributor.author | Koenig, A | - |
dc.contributor.author | Pieper, M | - |
dc.contributor.author | Rogers, JH | - |
dc.contributor.author | Wijns, W | - |
dc.contributor.author | Bose, D | - |
dc.contributor.author | Margolis, MP | - |
dc.contributor.author | Moses, JW | - |
dc.contributor.author | Stone, GW | - |
dc.contributor.author | Leon, MB | - |
dc.date.accessioned | 2011-05-13T05:12:08Z | - |
dc.date.available | 2011-05-13T05:12:08Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/2584 | - |
dc.description.abstract | OBJECTIVES: We used virtual histology intravascular ultrasound (VH-IVUS) to investigate the natural history of coronary artery lesion morphology.
BACKGROUND: Plaque stability is related to its histological composition. METHODS: We performed serial (baseline and 12-month follow-up) VH-IVUS studies and examined 216 nonculprit lesions (plaque burden >or=40%) in 99 patients. Lesions were classified into pathological intimal thickening (PIT), VH-IVUS-derived thin-capped fibroatheroma (VH-TCFA), thick-capped fibroatheroma (ThCFA), fibrotic plaque, and fibrocalcific plaque. RESULTS: At baseline, 20 lesions were VH-TCFAs; during follow-up, 15 (75%) VH-TCFAs "healed," 13 became ThCFAs, 2 became fibrotic plaque, and 5 (25%) VH-TCFAs remained unchanged. Compared with VH-TCFAs that healed, VH-TCFAs that remained VH-TCFAs located more proximally (values are median [interquartile range]) (16 mm [15 to 18 mm] vs. 31 mm [22 to 47 mm], p = 0.013) and had larger lumen (9.1 mm(2) [8.2 to 10.7 mm(2)] vs. 6.9 mm(2) [6.0 to 8.2 mm(2)], p = 0.021), vessel (18.7 mm(2) [17.3 to 28.6 mm(2)] vs. 15.5 mm(2) [13.3 to 16.6 mm(2)]; p = 0.010), and plaque (9.7 mm(2) [9.6 to 15.7 mm(2)] vs. 8.4 mm(2) [7 to 9.7 mm(2)], p = 0.027) areas; however, baseline VH-IVUS plaque composition did not differ between VH-TCFAs that healed and VH-TCFAs that remained VH-TCFAs. Conversely, 12 new VH-TCFAs developed; 6 late-developing VH-TCFAs were PITs, and 6 were ThCFAs at baseline. In addition, plaque area at minimum lumen sites increased significantly in PITs (7.8 mm(2) [6.2 to 10.0 mm(2)] to 9.0 mm(2) [6.5 to 12.0 mm(2)], p < 0.001), VH-TCFAs (8.6 mm(2) [7.3 to 9.9 mm(2)] to 9.5 mm(2) [7.8 to 10.8 mm(2)], p = 0.024), and ThCFAs (8.6 mm(2) [6.8 to 10.2 mm(2)] to 8.8 mm(2) [7.1 to 11.4 mm(2)], p < 0.001) with a corresponding decrease lumen areas, but not in fibrous or fibrocalcific plaque. CONCLUSIONS: Most VH-TCFAs healed during 12-month follow-up, whereas new VH-TCFAs also developed. PITs, VH-TCFAs, and ThCFAs showed significant plaque progression compared with fibrous and fibrocalcific plaque. | - |
dc.language.iso | en | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Coronary Artery Disease | - |
dc.subject.MESH | Coronary Vessels | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Histological Techniques | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Ultrasonography, Interventional | - |
dc.subject.MESH | User-Computer Interface | - |
dc.title | The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. | - |
dc.type | Article | - |
dc.identifier.pmid | 20378076 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(10)00500-0 | - |
dc.contributor.affiliatedAuthor | 최, 소연 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.jacc.2009.07.078 | - |
dc.citation.title | Journal of the American College of Cardiology | - |
dc.citation.volume | 55 | - |
dc.citation.number | 15 | - |
dc.citation.date | 2010 | - |
dc.citation.startPage | 1590 | - |
dc.citation.endPage | 1597 | - |
dc.identifier.bibliographicCitation | Journal of the American College of Cardiology, 55(15). : 1590-1597, 2010 | - |
dc.identifier.eissn | 1558-3597 | - |
dc.relation.journalid | J007351097 | - |
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