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The discovery of a common factor affecting Osteoarthritis and Parkinson's disease
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 양, 시영 | - |
| dc.contributor.author | 조, 찬미 | - |
| dc.date.accessioned | 2023-11-16T05:43:57Z | - |
| dc.date.available | 2023-11-16T05:43:57Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/26849 | - |
| dc.language.iso | en | - |
| dc.title | The discovery of a common factor affecting Osteoarthritis and Parkinson's disease | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000032442 | - |
| dc.subject.keyword | Osteoarthritis | - |
| dc.subject.keyword | DJ1 | - |
| dc.subject.keyword | SNCG | - |
| dc.subject.keyword | CD44 | - |
| dc.subject.keyword | LevNPs | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | 대학원 의생명과학과 | - |
| dc.contributor.affiliatedAuthor | 조, 찬미 | - |
| dc.date.awarded | 2023 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2023 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
| dc.description.tableOfContents | I. Introduction 1
1. Osteoarthritis and chondrocytes 1 2. Osteoarthritis and Parkinson’s disease 2 3. DJ1 and synuclein in Parkinson’s disease 4 4. Treatment of Osteoarthritis 6 5. CD44 in Osteoarthritis 7 6. Nanoparticle therapy and Levan 8 7. Aim of this study 9 II. Material and Methods 11 Human OA cartilage 11 Primary articular mouse chondrocyte culture 11 Cell viability analysis 13 RT-PCR and qRT-PCR 13 Western blot analysis 14 Experimental OA in mice 15 Preparation of LevNP 16 Chondrocyte explant culture and Alcian blue staining 17 Cartilage Tissue Histology, Immunohistochemistry Analyses, and Fluorescence Distribution Analyses 17 Confocal microarray imaging 19 Protein array 19 In silico chemical-protein binding assay 20 In silico analysis, microarray, and Ingenuity Pathway Analysis (IPA) 20 Statistical analysis 21 III. Results 22 Part I_The discovery of common disease factor between Parkinson’s disease and Osteoarthritis 22 Identification of common genes between PD and OA 22 Expression of DJ1 decreased in human and mouse OA cartilages 25 DJ1 depletion regulates OA-related factors in articular chondrocytes 25 DJ1 deficiency in cartilage tissue causes OA pathogenesis in mice 30 The identification of a down-mediator of DJ1 33 DJ1-induced γ-synuclein modulates OA Pathogenesis 36 γ-synuclein knockout in mice inhibits experimental OA pathogenesis 43 Secreted γ-synucleins affect chondrocytes in an autocrine manner 45 Identification of drugs that correlate with γ-synuclein expression using CMap 49 PART Ⅱ_ Nanotherapeutic material for OA treatment 51 Anti-Inflammatory Activity of LevNPs 51 Interaction Between LevNPs and CD44 53 Blockade of CD44 Protects Catabolic Factor Expression During OA Pathogenesis 57 Penetration Efficacy and Function of LevNPs in Mouse Cartilage 61 LevNPs reduce IL-1β induced ECM degradation and promote ECM synthesis in cartilage 67 Protection Against OA Pathogenesis via Intra-Articular Injection of LevNPs in Posttraumatic OA 69 IV. Discussion 73 V. Reference 84 국문 초록 99 | - |
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