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The efficacy of preoperative PET/CT for prediction of curability in surgery for locally advanced gastric carcinoma.

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dc.contributor.authorHur, H-
dc.contributor.authorKim, SH-
dc.contributor.authorKim, W-
dc.contributor.authorSong, KY-
dc.contributor.authorPark, CH-
dc.contributor.authorJeon, HM-
dc.date.accessioned2011-05-31T02:26:40Z-
dc.date.available2011-05-31T02:26:40Z-
dc.date.issued2010-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2737-
dc.description.abstractBACKGROUND: The benefits of preoperative 18FDG-PET/CT for gastric cancer remain uncertain. The aim of this study was to investigate the effects of preoperative 18FDG-PET/CT on the surgical strategy for locally advanced gastric cancer retrospectively.



METHODS: From January 2007 to November 2008, 18FDG-PET/CT was performed in 142 patients who had been diagnosed with advanced gastric cancer by computed tomography or gastrofiberscope findings.



RESULTS: Detection rates were 88.7% (126/142) for primary tumors and 24.6% (35/142) for local lymph nodes (LN). Nine patients with metastatic lesions underwent induction chemotherapy without operation. Of 133 patients subjected to operation, positive FDG uptake in primary tumors (p=0.047) and local lymph nodes (p<0.001) was related to non-curable operations. The mean standard uptake value (SUV) of primary tumors of patients who underwent non-curable operations was significantly higher than that of patients with curable operations (p=0.001). When the SUV was greater than 5 and FDG uptake of LN was positive, non-curable operations were predicted with a sensitivity of 35.2%, a specificity of 91.0% and an accuracy of 76.7%.



CONCLUSIONS: High SUV of the primary tumor and positive FDG uptake in local lymph nodes at PET/CT could predict non-curative resection in locally advanced gastric cancer. Therefore, information from preoperative PET/CT can help physician decisions regarding other modalities without laparotomy.
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dc.language.isoen-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGastrectomy-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPreoperative Care-
dc.subject.MESHPrognosis-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHStomach Neoplasms-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleThe efficacy of preoperative PET/CT for prediction of curability in surgery for locally advanced gastric carcinoma.-
dc.typeArticle-
dc.identifier.pmid20932345-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964718/-
dc.contributor.affiliatedAuthor허, 훈-
dc.type.localJournal Papers-
dc.identifier.doi10.1186/1477-7819-8-86-
dc.citation.titleWorld journal of surgical oncology-
dc.citation.volume8-
dc.citation.date2010-
dc.citation.startPage86-
dc.citation.endPage86-
dc.identifier.bibliographicCitationWorld journal of surgical oncology, 8. : 86-86, 2010-
dc.identifier.eissn1477-7819-
dc.relation.journalidJ014777819-
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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