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Activation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons.

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dc.contributor.authorJung, YS-
dc.contributor.authorLee, BK-
dc.contributor.authorPark, HS-
dc.contributor.authorShim, JK-
dc.contributor.authorKim, SU-
dc.contributor.authorLee, SH-
dc.contributor.authorBaik, EJ-
dc.contributor.authorMoon, CH-
dc.date.accessioned2011-06-13T04:23:18Z-
dc.date.available2011-06-13T04:23:18Z-
dc.date.issued2005-
dc.identifier.issn0959-4965-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2923-
dc.description.abstractWe investigated the role of individual protein kinase C (PKC) isoforms during kainate toxicity in cortical neurons. Treatment with 50 microM kainate induced isoform-specific activation of PKC-delta according to the translocation from the soluble to the particulate fraction, while it caused remarkable decreases in PKC alpha, beta, epsilon and zeta in both fractions. Kainate-induced neuronal death was significantly increased by pharmacological inhibition of PKC-delta with rottlerin, suggesting a protective role of PKC-delta against kainate toxicity. A PKC activator phorbol 12-myristate 13-acetate remarkably attenuated the kainate-induced neuronal death. Although phorbol 12-myristate 13-acetate activates PKC-epsilon and PKC-delta, the protective effect of phorbol 12-myristate 13-acetate was almost completely abolished by rottlerin, but not by epsilonV1-2. These results suggest that activation of PKC-delta attenuates the kainate-induced cell death of cortical neurons.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinogens-
dc.subject.MESHCell Death-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCerebral Cortex-
dc.subject.MESHExcitatory Amino Acid Agonists-
dc.subject.MESHIntracellular Signaling Peptides and Proteins-
dc.subject.MESHKainic Acid-
dc.subject.MESHMice-
dc.subject.MESHNeurons-
dc.subject.MESHProtein Kinase C-
dc.subject.MESHProtein Kinase C-delta-
dc.subject.MESHTetradecanoylphorbol Acetate-
dc.titleActivation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons.-
dc.typeArticle-
dc.identifier.pmid15858417-
dc.identifier.urlhttp://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0959-4965&volume=16&issue=7&spage=741-
dc.contributor.affiliatedAuthor정, 이숙-
dc.contributor.affiliatedAuthor김, 승업-
dc.contributor.affiliatedAuthor이, 수환-
dc.contributor.affiliatedAuthor백, 은주-
dc.contributor.affiliatedAuthor문, 창현-
dc.type.localJournal Papers-
dc.citation.titleNeuroreport-
dc.citation.volume16-
dc.citation.number7-
dc.citation.date2005-
dc.citation.startPage741-
dc.citation.endPage744-
dc.identifier.bibliographicCitationNeuroreport, 16(7). : 741-744, 2005-
dc.identifier.eissn1473-558X-
dc.relation.journalidJ009594965-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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