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The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha.
DC Field | Value | Language |
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dc.contributor.author | Yoo, YG | - |
dc.contributor.author | Cho, S | - |
dc.contributor.author | Park, S | - |
dc.contributor.author | Lee, MO | - |
dc.date.accessioned | 2011-06-28T04:33:28Z | - |
dc.date.available | 2011-06-28T04:33:28Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/3073 | - |
dc.description.abstract | Hepatitis B virus X protein (HBx) of the hepatitis B virus is strongly implicated in angiogenesis and metastasis during hepatocarcinogenesis. Previously, we reported that HBx enhances activity of hypoxia-inducible factor-1alpha (HIF-1alpha), a potent transactivator that induces angiogenic factors. Here, we delineate the structural region of HBx that potentiates HIF-1alpha. The carboxy-terminus of HBx increased the stability of HIF-1alpha protein, probably through inhibiting interaction with von Hippel-Lindau protein. Further, the carboxy-terminus of HBx enhanced the transactivation function of HIF-1alpha by enhancing its association with CREB binding protein (CBP). Finally, we demonstrated the physical association of HBx with the basic helix-loop-helix/PER-ARNT-SIM domain, the inhibitory domain, and the carboxy-terminal transactivation domain of HIF-1alpha in vivo. | - |
dc.language.iso | en | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1, alpha Subunit | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Trans-Activators | - |
dc.subject.MESH | Transcription Factors | - |
dc.subject.MESH | Transcription, Genetic | - |
dc.title | The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha. | - |
dc.type | Article | - |
dc.identifier.pmid | 15527772 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0014579304012086 | - |
dc.contributor.affiliatedAuthor | 박, 선 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.febslet.2004.10.004 | - |
dc.citation.title | FEBS letters | - |
dc.citation.volume | 577 | - |
dc.citation.number | 1-2 | - |
dc.citation.date | 2004 | - |
dc.citation.startPage | 121 | - |
dc.citation.endPage | 126 | - |
dc.identifier.bibliographicCitation | FEBS letters, 577(1-2). : 121-126, 2004 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.relation.journalid | J000145793 | - |
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