This study was to determine clinical entity of adult intussusception, focusing on discrepancies among previous studies and to retrospectively investigate the factors associated with malignancy and survival for 10 years. In our study, 3.7% (N = 42) of intussusception were adults. The most common symptom was acute abdominal pain (64.3%). Enteric, ileocolic, ileocecal, and colocolic intussusception included 52.4, 9.5, 14.3, and 23.8% of patients, respectively. Two patients (9.1%) with enteric (N = 22), no patient with ileocolic (N = 4), three patients (50%) with ileocecal (N = 6), and five patients (50%) with colocolic (N = 10) intussusception were malignant. The factor associated with malignancy was only chronic abdominal pain without acute abdominal pain (P = 0.018) and the absence of fever and ileocecal intussusception were associated with survival (P = 0.010, 0.009). In our study, the most common symptom was acute abdominal pain, and enteric intussusception was the most common type. The difference in clinical presentation and location of intussusception might have resulted from small number of cases or selection of cases.