Background: Compassion competence is a nurse’s ability to provide patient-centered care and communicate with patients in a sensitive and insightful manner. This descriptive cross-sectional survey study aimed to assess the compassion competence of a multinational group of nursing students. Method: A total of 1,158 undergraduate nursing students participated in this study, and stratified random sampling method was used to select participants from the 100 study level to the 400 or 500 level. Data were collected using the Compassion Competence Scale. Results: Significant differences were found in students grouped by country of residence, marital status, and level of study. Age had a significant relationship with compassion competence, whereas gender did not. Students had high mean scores on sensitivity to patient needs across all countries. Conclusion: Effective communication skills and insights into patient problems are important aspects of compassion competence, and undergraduate nursing programs should emphasize both of these aspects.