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Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes

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dc.contributor.authorKwak, SH-
dc.contributor.authorHernandez-Cancela, RB-
dc.contributor.authorDiCorpo, DA-
dc.contributor.authorCondon, DE-
dc.contributor.authorMerino, J-
dc.contributor.authorWu, P-
dc.contributor.authorBrody, JA-
dc.contributor.authorYao, J-
dc.contributor.authorGuo, X-
dc.contributor.authorAhmadizar, F-
dc.contributor.authorMeyer, M-
dc.contributor.authorSincan, M-
dc.contributor.authorMercader, JM-
dc.contributor.authorLee, S-
dc.contributor.authorHaessler, J-
dc.contributor.authorVy, HMT-
dc.contributor.authorLin, Z-
dc.contributor.authorArmstrong, ND-
dc.contributor.authorGu, S-
dc.contributor.authorTsao, NL-
dc.contributor.authorLange, LA-
dc.contributor.authorWang, N-
dc.contributor.authorWiggins, KL-
dc.contributor.authorTrompet, S-
dc.contributor.authorLiu, S-
dc.contributor.authorLoos, RJF-
dc.contributor.authorJudy, R-
dc.contributor.authorSchroeder, PH-
dc.contributor.authorHasbani, NR-
dc.contributor.authorBos, MM-
dc.contributor.authorMorrison, AC-
dc.contributor.authorJackson, RD-
dc.contributor.authorReiner, AP-
dc.contributor.authorManson, JE-
dc.contributor.authorChaudhary, NS-
dc.contributor.authorCarmichael, LK-
dc.contributor.authorChen, YI-
dc.contributor.authorTaylor, KD-
dc.contributor.authorGhanbari, M-
dc.contributor.authorvan Meurs, J-
dc.contributor.authorPitsillides, AN-
dc.contributor.authorPsaty, BM-
dc.contributor.authorNoordam, R-
dc.contributor.authorDo, R-
dc.contributor.authorPark, KS-
dc.contributor.authorJukema, JW-
dc.contributor.authorKavousi, M-
dc.contributor.authorCorrea, A-
dc.contributor.authorRich, SS-
dc.contributor.authorDamrauer, SM-
dc.contributor.authorHajek, C-
dc.contributor.authorCho, NH-
dc.contributor.authorIrvin, MR-
dc.contributor.authorPankow, JS-
dc.contributor.authorNadkarni, GN-
dc.contributor.authorSladek, R-
dc.contributor.authorGoodarzi, MO-
dc.contributor.authorFlorez, JC-
dc.contributor.authorChasman, DI-
dc.contributor.authorHeckbert, SR-
dc.contributor.authorKooperberg, C-
dc.contributor.authorDupuis, J-
dc.contributor.authorMalhotra, R-
dc.contributor.authorde Vries, PS-
dc.contributor.authorLiu, CT-
dc.contributor.authorRotter, JI-
dc.contributor.authorMeigs, JB-
dc.contributor.authorCohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium-
dc.date.accessioned2024-07-05T01:28:02Z-
dc.date.available2024-07-05T01:28:02Z-
dc.date.issued2024-
dc.identifier.issn0149-5992-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32600-
dc.description.abstractOBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16). CONCLUSIONS: The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHCardiovascular Diseases-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHFemale-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.titleTime-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes-
dc.typeArticle-
dc.identifier.pmid38652672-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116923-
dc.contributor.affiliatedAuthorCho, NH-
dc.type.localJournal Papers-
dc.identifier.doi10.2337/dc23-2274-
dc.citation.titleDiabetes care-
dc.citation.volume47-
dc.citation.number6-
dc.citation.date2024-
dc.citation.startPage1042-
dc.citation.endPage1047-
dc.identifier.bibliographicCitationDiabetes care, 47(6). : 1042-1047, 2024-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1935-5548-
dc.relation.journalidJ001495992-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
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