Cited 0 times in Scipus Cited Count

Spatio-temporal analysis of genetic diversity of merozoite surface protein-3 alpha in Myanmar Plasmodium vivax isolates

DC Field Value Language
dc.contributor.authorVo, TC-
dc.contributor.authorKang, JM-
dc.contributor.authorLe, HG-
dc.contributor.authorNaw, H-
dc.contributor.authorKim, TS-
dc.contributor.authorShin, HJ-
dc.contributor.authorMyint, MK-
dc.contributor.authorHtun, ZT-
dc.contributor.authorNa, BK-
dc.date.accessioned2024-09-10T06:21:44Z-
dc.date.available2024-09-10T06:21:44Z-
dc.date.issued2024-
dc.identifier.issn1567-1348-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32747-
dc.description.abstractMyanmar aims to eliminate malaria by 2030. However, recent increase of malaria incidence is a great challenge to archive that goal. Increasing prevalence of Plasmodium vivax also hinders this endeavor. Monitoring genetic structure of the parasite is necessary to understand genetic nature and evolutionary aspect of P. vivax population in Myanmar. Partial fragment flanking blocks I and II of merozoite surface protein-3 alpha of P. vivax (pvmsp-3α) was amplified from P. vivax isolates collected in Pyin Oo Lwin, Mandalay Region, Myanmar in 2013–2015. Sequence analysis of pvmsp-3α was performed to determine genetic diversity and natural selection of this gene. Spatio-temporal genetic changes of pvmsp-3α in Myanmar P. vivax population were also investigated via comparative analysis of gene sequences obtained in this study and previously reported Myanmar pvmsp-3α sequences. Genetic diversity of Myanmar pvmsp-3α was detected in P. vivax isolates analyzed. Size polymorphisms in block I and amino acid changes and recombination events in block II were main factors contributing to the genetic diversity of pvmsp-3α. Comparative spatio-temporal analysis with previously reported Myanmar pvmsp-3α populations revealed the presence of genetic differences by population with moderate genetic differentiation between populations. Similar pattern of natural selection was also detected in Myanmar pvmsp-3α populations. These suggested that enough size of the P. vivax population sufficient to generate or maintain the genetic diversity remains in the population. Thus, continuous molecular surveillance of genetic structure of Myanmar P. vivax is necessary.-
dc.language.isoen-
dc.subject.MESHAntigens, Protozoan-
dc.subject.MESHGenetic Variation-
dc.subject.MESHHumans-
dc.subject.MESHMalaria, Vivax-
dc.subject.MESHMyanmar-
dc.subject.MESHPhylogeny-
dc.subject.MESHPlasmodium vivax-
dc.subject.MESHProtozoan Proteins-
dc.subject.MESHSelection, Genetic-
dc.subject.MESHSpatio-Temporal Analysis-
dc.titleSpatio-temporal analysis of genetic diversity of merozoite surface protein-3 alpha in Myanmar Plasmodium vivax isolates-
dc.typeArticle-
dc.identifier.pmid38997058-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1567-1348(24)00090-X-
dc.subject.keywordGenetic diversity-
dc.subject.keywordMerozoite surface protein–3 alpha-
dc.subject.keywordMyanmar-
dc.subject.keywordPlasmodium vivax-
dc.contributor.affiliatedAuthorShin, HJ-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.meegid.2024.105639-
dc.citation.titleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases-
dc.citation.volume123-
dc.citation.date2024-
dc.citation.startPage105639-
dc.citation.endPage105639-
dc.identifier.bibliographicCitationInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 123. : 105639-105639, 2024-
dc.identifier.eissn1567-7257-
dc.relation.journalidJ015671348-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Files in This Item:
38997058.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse