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The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors.

DC Field Value Language
dc.contributor.authorRyu, BR-
dc.contributor.authorLee, YA-
dc.contributor.authorWon, SJ-
dc.contributor.authorNoh, JH-
dc.contributor.authorChang, SY-
dc.contributor.authorChung, JM-
dc.contributor.authorChoi, JS-
dc.contributor.authorJoo, CK-
dc.contributor.authorYoon, SH-
dc.contributor.authorGwag, BJ-
dc.date.accessioned2011-07-13T02:07:20Z-
dc.date.available2011-07-13T02:07:20Z-
dc.date.issued2003-
dc.identifier.issn0022-3565-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3297-
dc.description.abstractSulfasalazine is widely used to treat inflammatory diseases. Besides anti-inflammatory actions such as blockade of nuclear factor-kappaB and cyclooxygenases, we found that 30 to 1000 micro M sulfasalazine dose dependently blocked N-methyl-D-aspartate receptor-mediated excitotoxicity without intervening kainate or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid neurotoxicity. The neuroprotective effects of sulfasalazine were attributable to prevention of Ca(2+) influx and accumulation through N-methyl-D-aspartate receptors as a low-affinity antagonist. The systemic administration of sulfasalazine reduced neuronal death following transient cerebral and retinal ischemia in adult rat. The present findings suggest that the neuroprotective action of sulfasalazine can be therapeutically applied to halt devastating neuronal death following hypoxic ischemia, trauma, and neurodegenerative diseases.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants-
dc.subject.MESHCalcium-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCerebral Cortex-
dc.subject.MESHCyclooxygenase 2-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHIschemia-
dc.subject.MESHIsoenzymes-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHN-Methylaspartate-
dc.subject.MESHNF-kappa B-
dc.subject.MESHNeuroprotective Agents-
dc.subject.MESHProstaglandin-Endoperoxide Synthases-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, N-Methyl-D-Aspartate-
dc.subject.MESHRetinal Diseases-
dc.subject.MESHSulfasalazine-
dc.titleThe novel neuroprotective action of sulfasalazine through blockade of NMDA receptors.-
dc.typeArticle-
dc.identifier.pmid12649352-
dc.identifier.urlhttp://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12649352-
dc.contributor.affiliatedAuthor곽, 병주-
dc.type.localJournal Papers-
dc.identifier.doi10.1124/jpet.102.042606-
dc.citation.titleThe Journal of pharmacology and experimental therapeutics-
dc.citation.volume305-
dc.citation.number1-
dc.citation.date2003-
dc.citation.startPage48-
dc.citation.endPage56-
dc.identifier.bibliographicCitationThe Journal of pharmacology and experimental therapeutics, 305(1). : 48-56, 2003-
dc.identifier.eissn1521-0103-
dc.relation.journalidJ000223565-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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