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Biological monitoring of bisphenol a in a Korean population.

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dc.contributor.authorYang, M-
dc.contributor.authorKim, SY-
dc.contributor.authorLee, SM-
dc.contributor.authorChang, SS-
dc.contributor.authorKawamoto, T-
dc.contributor.authorJang, JY-
dc.contributor.authorAhn, YO-
dc.date.accessioned2011-07-13T05:40:51Z-
dc.date.available2011-07-13T05:40:51Z-
dc.date.issued2003-
dc.identifier.issn0090-4341-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3319-
dc.description.abstractTo conduct proper biological monitoring of environmental exposure to bisphenol A (BPA), the variation in host susceptibility need to be investigated. For this purpose, we studied effects of genetic polymorphism in sulfotransferase (SULT) 1A1 on urinary BPA, a biomarker for BPA exposure, in 73 Koreans (male, 34; female, 39; age, 48.9 +/- 11.9 yrs). We used reverse phase-HPLC/FD for analysis of urinary BPA and obtained information from each subject on lifestyle, environment, and potential exposure to BPA via food. The HPLC/FD method showed good reproducibility (CVs < 0.1) and a relatively sensitive detection limit of 0.012 microg/L. These methods yielded a geometric mean of urinary BPA as 9.54 microg/L (8.91 microg/g creatinine), with a geometric standard deviation of 8.32 microg/L. Among potential routes for BPA exposure, only "vinyl wrapping of microwave heating" indicated a borderline positive association with urinary BPA level (p = 0.1). After PCR-RFLP, we found the allele frequencies of SULT1A1*1 and SULT1A1*2 were 0.89 and 0.11, respectively within the subjects. As the SULT1A1*1 allele of SULT1A1 is known to be a rapid sulfonylation-allele, the presence of SULT1A1*1 is suspected to rapidly dispose of environmental BPA. However resultant, urinary BPA levels were not significantly different between the SULT1A1*1/*1 identified subjects and the SULT1A1*1/*2 subjects. Therefore, to clarify host variability in urinary BPA level, different genetic polymorphisms in BPA metabolic enzymes other than SULT1A1 should be further studied.-
dc.language.isoen-
dc.subject.MESHArylsulfotransferase-
dc.subject.MESHEnvironmental Exposure-
dc.subject.MESHEnvironmental Monitoring-
dc.subject.MESHEnvironmental Pollutants-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Markers-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhenols-
dc.subject.MESHPolymorphism, Genetic-
dc.subject.MESHSulfotransferases-
dc.titleBiological monitoring of bisphenol a in a Korean population.-
dc.typeArticle-
dc.identifier.pmid12712285-
dc.contributor.affiliatedAuthor장, 재연-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00244-002-2124-0-
dc.citation.titleArchives of environmental contamination and toxicology-
dc.citation.volume44-
dc.citation.number4-
dc.citation.date2003-
dc.citation.startPage546-
dc.citation.endPage551-
dc.identifier.bibliographicCitationArchives of environmental contamination and toxicology, 44(4). : 546-551, 2003-
dc.identifier.eissn1432-0703-
dc.relation.journalidJ000904341-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
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