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Biological monitoring of bisphenol a in a Korean population.
DC Field | Value | Language |
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dc.contributor.author | Yang, M | - |
dc.contributor.author | Kim, SY | - |
dc.contributor.author | Lee, SM | - |
dc.contributor.author | Chang, SS | - |
dc.contributor.author | Kawamoto, T | - |
dc.contributor.author | Jang, JY | - |
dc.contributor.author | Ahn, YO | - |
dc.date.accessioned | 2011-07-13T05:40:51Z | - |
dc.date.available | 2011-07-13T05:40:51Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0090-4341 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/3319 | - |
dc.description.abstract | To conduct proper biological monitoring of environmental exposure to bisphenol A (BPA), the variation in host susceptibility need to be investigated. For this purpose, we studied effects of genetic polymorphism in sulfotransferase (SULT) 1A1 on urinary BPA, a biomarker for BPA exposure, in 73 Koreans (male, 34; female, 39; age, 48.9 +/- 11.9 yrs). We used reverse phase-HPLC/FD for analysis of urinary BPA and obtained information from each subject on lifestyle, environment, and potential exposure to BPA via food. The HPLC/FD method showed good reproducibility (CVs < 0.1) and a relatively sensitive detection limit of 0.012 microg/L. These methods yielded a geometric mean of urinary BPA as 9.54 microg/L (8.91 microg/g creatinine), with a geometric standard deviation of 8.32 microg/L. Among potential routes for BPA exposure, only "vinyl wrapping of microwave heating" indicated a borderline positive association with urinary BPA level (p = 0.1). After PCR-RFLP, we found the allele frequencies of SULT1A1*1 and SULT1A1*2 were 0.89 and 0.11, respectively within the subjects. As the SULT1A1*1 allele of SULT1A1 is known to be a rapid sulfonylation-allele, the presence of SULT1A1*1 is suspected to rapidly dispose of environmental BPA. However resultant, urinary BPA levels were not significantly different between the SULT1A1*1/*1 identified subjects and the SULT1A1*1/*2 subjects. Therefore, to clarify host variability in urinary BPA level, different genetic polymorphisms in BPA metabolic enzymes other than SULT1A1 should be further studied. | - |
dc.language.iso | en | - |
dc.subject.MESH | Arylsulfotransferase | - |
dc.subject.MESH | Environmental Exposure | - |
dc.subject.MESH | Environmental Monitoring | - |
dc.subject.MESH | Environmental Pollutants | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Markers | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phenols | - |
dc.subject.MESH | Polymorphism, Genetic | - |
dc.subject.MESH | Sulfotransferases | - |
dc.title | Biological monitoring of bisphenol a in a Korean population. | - |
dc.type | Article | - |
dc.identifier.pmid | 12712285 | - |
dc.contributor.affiliatedAuthor | 장, 재연 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s00244-002-2124-0 | - |
dc.citation.title | Archives of environmental contamination and toxicology | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.date | 2003 | - |
dc.citation.startPage | 546 | - |
dc.citation.endPage | 551 | - |
dc.identifier.bibliographicCitation | Archives of environmental contamination and toxicology, 44(4). : 546-551, 2003 | - |
dc.identifier.eissn | 1432-0703 | - |
dc.relation.journalid | J000904341 | - |
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