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Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus.
DC Field | Value | Language |
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dc.contributor.author | Ryu, JK | - |
dc.contributor.author | Franciosi, S | - |
dc.contributor.author | Sattayaprasert, P | - |
dc.contributor.author | Kim, SU | - |
dc.contributor.author | McLarnon, JG | - |
dc.date.accessioned | 2011-07-15T02:56:57Z | - |
dc.date.available | 2011-07-15T02:56:57Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0894-1491 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/3378 | - |
dc.description.abstract | Minocycline, a second-generation tetracycline compound, has been examined as a neuroprotectant in beta-amyloid (A beta)-injected rat hippocampus. At 7 days post-injection, A beta(1-42) caused a significant loss of granule cell layer neurons (28% reduction) compared to control uninjected hippocampus. Hippocampal injection of A beta peptide also led to marked gliosis with numbers of microglia (increased by 26-fold) and immunoreactivity of astrocytes (increased by 11-fold) relative to control, as determined from immunohistochemical analysis. Intraperitoneal administration of minocycline significantly reduced neuronal loss induced by A beta(1-42) (by 80%) and also diminished numbers of microglia (by 69%) and astrocytes (by 36%) relative to peptide alone. Peptide injection increased expression of cyclooxygenase-2 (COX-2) in most (about 70%) of granule cells, a subset (about 20%) of microglia, but not in astrocytes; in the presence of minocycline, COX-2 immunostaining was abolished in microglia. The results from this study suggest that minocycline may have efficacy in the treatment of AD. | - |
dc.language.iso | en | - |
dc.subject.MESH | Amyloid beta-Peptides | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Bacterial Agents | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject.MESH | Astrocytes | - |
dc.subject.MESH | Cell Death | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | Gliosis | - |
dc.subject.MESH | Hippocampus | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Isoenzymes | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Minocycline | - |
dc.subject.MESH | Nerve Degeneration | - |
dc.subject.MESH | Neuroglia | - |
dc.subject.MESH | Neurons | - |
dc.subject.MESH | Neuroprotective Agents | - |
dc.subject.MESH | Prostaglandin-Endoperoxide Synthases | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus. | - |
dc.type | Article | - |
dc.identifier.pmid | 15326618 | - |
dc.contributor.affiliatedAuthor | 김, 승업 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1002/glia.20051 | - |
dc.citation.title | Glia | - |
dc.citation.volume | 48 | - |
dc.citation.number | 1 | - |
dc.citation.date | 2004 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | Glia, 48(1). : 85-90, 2004 | - |
dc.identifier.eissn | 1098-1136 | - |
dc.relation.journalid | J008941491 | - |
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