Cited 0 times in Scipus Cited Count

Insulin and glucagon secretions, and morphological change of pancreatic islets in OLETF rats, a model of type 2 diabetes mellitus.

DC Field Value Language
dc.contributor.authorHong, EG-
dc.contributor.authorNoh, HL-
dc.contributor.authorLee, SK-
dc.contributor.authorChung, YS-
dc.contributor.authorLee, KW-
dc.contributor.authorKim, HM-
dc.date.accessioned2011-07-20T01:46:23Z-
dc.date.available2011-07-20T01:46:23Z-
dc.date.issued2002-
dc.identifier.issn1011-8934-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3470-
dc.description.abstractThis study was performed to observe the changes of glucose-related hormones and the morphological change including ultrastructure of the pancreatic islets in the male Otsuka Long-Evans Tokushima Fatty rat. Area under the curve (AUC) of glucose at the 30th (709 plus minus 73 mg.h/dL) and at the 40th week (746 plus minus 87 mg.h/ dL) of age were significantly higher than that at the 10th week (360 plus minus 25 mg.h/ dL). AUC of insulin of the 10th week was 2.4 plus minus 0.9 ng.h/mL, increased gradually to 10.8 plus minus 8.3 ng.h/mL at the 30th week, and decreased to 1.8 plus minus 1.2 ng.h/mL at the 40th week. The size of islet was increased at 20th week of age and the distribution of peripheral alpha cells and central beta cells at the 10th and 20th weeks was changed to a mixed pattern at the 40th week. On electron microscopic examination, beta cells at the 20th week showed many immature secretory granules, increased mitochondria, and hypertrophied Golgi complex and endoplasmic reticulum. At the 40th week, beta cell contained scanty intracellular organelles and secretory granules and apoptosis of acinar cell was observed. In conclusion, as diabetes progressed, increased secretion of insulin was accompanied by increases in size of islets and number of beta-cells in male OLETF rats showing obese type 2 diabetes. However, these compensatory changes could not overcome the requirement of insulin according to the continuous hyperglycemia after development of diabetes.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBody Weight-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHGlucagon-
dc.subject.MESHInsulin-
dc.subject.MESHIslets of Langerhans-
dc.subject.MESHMale-
dc.subject.MESHRats-
dc.subject.MESHRats, Inbred OLETF-
dc.titleInsulin and glucagon secretions, and morphological change of pancreatic islets in OLETF rats, a model of type 2 diabetes mellitus.-
dc.typeArticle-
dc.identifier.pmid11850586-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054832/-
dc.contributor.affiliatedAuthor정, 윤석-
dc.contributor.affiliatedAuthor이, 관우-
dc.contributor.affiliatedAuthor김, 현만-
dc.type.localJournal Papers-
dc.identifier.doi10.3346/jkms.2002.17.1.34-
dc.citation.titleJournal of Korean medical science-
dc.citation.volume17-
dc.citation.number1-
dc.citation.date2002-
dc.citation.startPage34-
dc.citation.endPage40-
dc.identifier.bibliographicCitationJournal of Korean medical science, 17(1). : 34-40, 2002-
dc.identifier.eissn1598-6357-
dc.relation.journalidJ010118934-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Files in This Item:
11850586.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse